Age-dependent amyloid deposition is associated with white matter alterations in cognitively normal adults during the adult life span.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Miguel Á Araque CaballeroMichael Ewers

Abstract

Both beta-amyloid (Ab) deposition and decline in white matter integrity, are brain alterations observed in Alzheimer's disease (AD) and start to occur by the fourth and fifth decades. However, the association between both brain alterations in asymptomatic subjects is unclear. Amyloid positron emission tomography (PET) and diffusion tensor imaging (DTI) were obtained in 282 cognitively normal subjects (age 30-89 years). We assessed the interaction of age by abnormal amyloid PET status (Florbetapir F-18 PET >1.2 standard uptake value ratio [SUVR]) on regional mean diffusivity (MD) and global white matter hyperintensity (WMH) volume, controlled for sex, education, and hypertension. Subjects with abnormal amyloid PET (n = 87) showed stronger age-related increase in global WMH and regional MD, particularly within the posterior parietal regions of the white matter. Sporadic Aβ deposition is associated with white matter alterations in AD predilection areas in an age-dependent manner in cognitively normal individuals.

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Citations

Aug 19, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sofia FinsterwalderMarco Duering
Sep 29, 2020·Frontiers in Neurology·Hae Won KimJae Cheon Jeon
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Jan 22, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Alexis MoscosoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Nov 17, 2020·Frontiers in Aging Neuroscience·Natalia SalvadoresFelipe A Court
Mar 31, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Rachel F Buckley
Apr 6, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Lyduine E CollijAnouk Den Braber
Jun 18, 2021·Brain Communications·Sheelakumari RaghavanPrashanthi Vemuri
Sep 29, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Alexis MoscosoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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