Age-dependent changes in contraction and regional myocardial myosin heavy chain isoform expression in rats

Journal of Applied Physiology
Cynthia A CarnesPeter J Reiser

Abstract

The goals of this study were to measure the relative levels of the alpha- and beta-isoforms of myosin heavy chain (MHC-alpha and MHC-beta, respectively) in multiple, specific regions of the adult rat heart and to determine whether age-dependent changes in isoform levels in different regions are uniform. Relative amounts of MHC-alpha and MHC-beta were determined in right and left atria and left ventricular (LV) Purkinje fibers (PF), papillary muscles, trabeculae, and endo-, mid-, and epicardial regions at 2, 5, 10, 16, and 21 mo. PFs contained substantial amounts of myosin and were striated and capable of generating force and shortening on activation. Levels of MHC-beta increased in all LV compartments with age, especially between 2 and 5 mo. There was more MHC-beta in PFs than other LV sites. There were regional differences in the level of MHC-beta throughout the LV at all ages, and the rates of change within regions differed. Ca(2+)-activated tension in PFs and trabeculae was compared at 2 and 22 mo. PF tension was less than trabecula tension, and this difference may be explained by differences in MHC content. V(max) and tension-generating ability in PFs decreased with age. Maximal tension generated by trabeculae did not chang...Continue Reading

References

Nov 1, 1979·Nature·A M LompreB Swynghedauw
Oct 22, 1979·The American Journal of Cardiology·N R AlpertR Z Litten
May 1, 1978·Journal of Molecular and Cellular Cardiology·J P FroehlichG Gerstenblith
Oct 1, 1990·Mechanisms of Ageing and Development·G T Schuyler, L R Yarbrough
Dec 1, 1986·Journal of the American College of Cardiology·P AnversaG Olivetti
Jul 1, 1983·The American Journal of Physiology·J M CapassoE H Sonnenblick
Jun 1, 1984·The American Journal of Physiology·J Y WeiE G Lakatta
Feb 23, 1994·Molecular and Cellular Biochemistry·R L Toffolo, C D Ianuzzo
May 21, 1998·Mechanisms of Ageing and Development·G AnnoniS Masson
Feb 23, 1999·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·X LongE G Lakatta
May 18, 1999·The American Journal of Physiology·D P FitzsimonsR L Moss
Aug 13, 1999·The American Journal of Physiology·J Wattanapermpool, P J Reiser
Sep 25, 1999·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M O BoluytT P White
Apr 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A C ZygmuntC Antzelevitch
Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·P A WahrJ M Metzger
Mar 10, 2001·The International Journal of Biochemistry & Cell Biology·R R Nair, P Nair
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T J HerronK S McDonald

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Citations

Feb 22, 2011·Pflügers Archiv : European journal of physiology·Olivier Cazorla, Alain Lacampagne
Dec 7, 2007·Cardiovascular Research·Nazha HamdaniJolanda van der Velden
Sep 8, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Eunhee Chung, Gary M Diffee
Jul 31, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Eunhee Chung, Gary M Diffee
Aug 13, 2011·Journal of the Royal Society, Interface·Stuart G Campbell, Andrew D McCulloch
Jul 3, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Stuart G CampbellAndrew D McCulloch
Aug 24, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Yong ChenJulian E Stelzer
Apr 28, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Matthew R LocherRichard L Moss
Aug 19, 2011·Heart Failure Reviews·Naranjan S DhallaVijayan Elimban
Dec 2, 2006·The Journal of Physiology·Julian E StelzerRichard L Moss
Dec 3, 2014·Biochimica Et Biophysica Acta·Zhiyong YinWei Guo
Jul 28, 2016·Age·Beatriz Martín-Fernández, Ricardo Gredilla
Oct 17, 2008·Physiological Reviews·Jennifer DavisJoseph M Metzger
Mar 7, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Kevin BoldtWalter Herzog
Jan 4, 2019·The Journal of General Physiology·Sherif M RedaMurali Chandra
Dec 1, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Chutima RattanasopaJonggonnee Wattanapermpool
Oct 30, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Janusz H HankiewiczE Douglas Lewandowski
Jun 25, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Stuart G CampbellKenneth S Campbell
Jul 1, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Kevin BoldtWalter Herzog
Jul 28, 2020·Progress in Biophysics and Molecular Biology·Francesca MargaraBlanca Rodriguez
Sep 22, 2020·Mechanisms of Ageing and Development·Kevin BoldtWalter Herzog

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