Age-dependent changes in the immunoreactivity for neurofilaments in rabbit hippocampus

Neuroscience
E A Van der ZeeJ F Disterhoft

Abstract

The distribution of the three subunits of neurofilaments was examined in the hippocampus of young adult rabbits (three months of age), employing a panel of six monoclonal antibodies. Thereafter, age-dependent and subunit-selective changes in neurofilament immunoreactivity in the ageing rabbit hippocampus were studied, using animals of one, three, six, 12, 24, 30, 36, 48, and 60 months. Principal cells, interneurons, axons, and various fibre systems were immunoreactive for all three subunits, although the localization and staining intensity of neurofilament immunoreactivity depended on the antibody used. Small cells immunopositive for the low subunit of neurofilament (presumably glial cells) were found abundantly in the hippocampal formation at one month, and (occasionally) at 30-36 months. Young rabbits (one to three months of age) had high numbers of interneurons stained for the high subunit of neurofilament in the stratum oriens/pyramidale. The number declined and plateaued to approximately 78% at six to 30 months, and further declined and plateaued to approximately 56% at 36-60 months. The first decline may reflect a process of maturation, while the latter decline most likely relates to ageing. Ageing pyramidal cells in 48-6...Continue Reading

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Apr 2, 1999·Trends in Pharmacological Sciences·C A Altar
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