Age-dependent development and clinical characteristics of an experimental parrot bornavirus-4 (PaBV-4) infection in cockatiels (Nymphicus hollandicus).

Avian Pathology : Journal of the W.V.P.A
Anna Maria GartnerMichael Lierz

Abstract

Parrot bornavirus (PaBV) is a pathogen often found in psittacine populations. Infected, clinically healthy carrier birds are of major importance for epidemiology, but the underlying pathomechanism of this carrier status is poorly understood. The age, implying the maturation status of the immune system, at the time of infection might be significant for the clinical outcome. Therefore, two groups of 11 cockatiels of different ages (adult and newly hatched) were inoculated with a PaBV-4 isolate intravenously. The trial lasted for 233 days and all birds were observed for clinical signs, PaBV-RNA shedding and anti-PaBV antibody production. At the end of the trial, histopathology, immunohistochemistry, PCR and virus re-isolation were performed. All 22 birds seroconverted and shed PaBV-RNA during the investigation period; the juvenile group earlier and more homogeneously. Nine of 11 birds of the adult group developed clinical signs; five birds died or had to be euthanized before the end of the study. In the juvenile group none of the birds developed clinical signs and only one bird died due to bacterial septicaemia. Eight birds of the adult group, but none of the juvenile group, showed a dilatation of the proventriculus. PaBV-RNA dete...Continue Reading

References

Nov 11, 1991·Journal of Virology·K M CarboneG B Vogelsang
Nov 1, 1988·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·R RottL Stitz
Jul 1, 1983·The Journal of General Virology·N HiranoH Ludwig
Jan 1, 1984·Medical Microbiology and Immunology·S HerzogR Rott
Sep 1, 1981·Poultry Science·F Seto
May 1, 1994·The Journal of Experimental Medicine·J A RichtR Rott
Jan 1, 1993·Journal of Virology·S A RubinK M Carbone
Dec 21, 1995·Brain Research. Developmental Brain Research·J R BautistaK M Carbone
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·M HornigW I Lipkin
Dec 22, 1999·Journal of Neurovirology·T BrieseW I Lipkin
Jan 30, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Lothar StitzOliver Planz
Nov 9, 2002·The Journal of Infectious Diseases·Juan Carlos de la Torre
Dec 3, 2008·Emerging Infectious Diseases·Kirsi S HonkavuoriW Ian Lipkin
Oct 1, 2001·Avian Pathology : Journal of the W.V.P.A·Y BerhaneB Hunter
Mar 6, 2010·Emerging Infectious Diseases·Patricia GrayIan Tizard
Apr 16, 2010·Journal of Clinical Microbiology·Sibylle HerzogChristiane Herden
Jul 14, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Raj RaghavDale A Smith
Aug 5, 2010·The Veterinary Clinics of North America. Exotic Animal Practice·Sharman HoppesIan Tizard
Dec 17, 2011·Emerging Infectious Diseases·Michael LierzDirk Enderlein
Feb 7, 2012·Emerging Infectious Diseases·Anne K PiepenbringMichael Lierz
Nov 25, 2014·Emerging Infectious Diseases·Nuri Encinas-NagelMichael Lierz
Jul 15, 2015·The New England Journal of Medicine·Bernd HoffmannMartin Beer
Apr 23, 2016·Avian Pathology : Journal of the W.V.P.A·Anne K PiepenbringMichael Lierz
Nov 18, 2017·The Veterinary Clinics of North America. Exotic Animal Practice·Giacomo RossiSusan E Orosz
Oct 4, 2018·The New England Journal of Medicine·Kore SchlottauMartin Beer

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
reverse transcription PCR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.