Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein

Science
J M BallM K Estes

Abstract

The rotavirus nonstructural glycoprotein NSP4 is an intracellular receptor that mediates the acquisition of a transient membrane envelope as subviral particles bud into the endoplasmic reticulum. NSP4 also causes an increase in intracellular calcium in insect cells. Purified NSP4 or a peptide corresponding to NSP4 residues 114 to 135 induced diarrhea in young (6 to 10 days old) CD1 mice. This disease response was age-dependent, dose-dependent, and specific. Electrophysiologic data from intestinal mucosa showed that the NSP4 114-135 peptide potentiates chloride secretion by a calcium-dependent signaling pathway. Diarrhea is induced when NSP4, acting as a viral enterotoxin, triggers a signal transduction pathway.

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M FieldP L Smith
Jul 1, 1976·The American Journal of Digestive Diseases·C A Mebus
Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M G CurrieC E Smith
Oct 1, 1990·Journal of Virology·R L WardJ F Sheridan
Dec 14, 1990·Science·J N XiM K Estes
Mar 1, 1988·Journal of Pediatric Gastroenterology and Nutrition·M P OsborneJ Stephen
Mar 1, 1988·Journal of Pediatric Gastroenterology and Nutrition·J CollinsJ Stephen
Dec 1, 1986·The Journal of General Virology·W G StarkeyJ Stephen
Jan 1, 1980·Scandinavian Journal of Infectious Diseases·J Halvorsrud, I Orstavik
Nov 1, 1982·Infection and Immunity·L M Little, J A Shadduck
Nov 1, 1984·Digestive Diseases and Sciences·D Y GrahamM K Estes
Jan 1, 1981·Annual Review of Medicine·R A Giannella
Mar 1, 1980·The Journal of Infection·H HolzelJ Church
May 2, 1994·Journal of Immunological Methods·J M BallM J Newman
Mar 1, 1995·The American Journal of Physiology·B R Grubb
Feb 20, 1995·Virology·J W BurnsH B Greenberg

❮ Previous
Next ❯

Citations

May 23, 1998·Journal of Medical Virology·H WuS Urasawa
Sep 29, 1999·Journal of Medical Virology·K JohansenL Svensson
Mar 10, 2001·Journal of Medical Virology·C N LeeH N Chen
Mar 16, 2007·Pflügers Archiv : European journal of physiology·Karl KunzelmannRainer Schreiber
Mar 15, 2011·Pflügers Archiv : European journal of physiology·Jiraporn OusingsawatKarl Kunzelmann
May 25, 2011·Pflügers Archiv : European journal of physiology·Karl KunzelmannRainer Schreiber
Sep 22, 2000·Current Gastroenterology Reports·A J Janecki
Apr 6, 2004·Advanced Drug Delivery Reviews·V K ViswanathanGail Hecht
May 7, 2005·Journal of Ethnopharmacology·J L S GonçalvesM D Wigg
May 19, 2005·Journal of Virological Methods·E Guzman, M A McCrae
Feb 6, 2004·Toxicon : Official Journal of the International Society on Toxinology·Karina N LaohachaiJoseph I Kourie
Sep 25, 2002·Journal of Virological Methods·Kathleen M TattiRoger Glass
Jul 13, 2000·Brain & Development·T AbeH Ushijima
Oct 11, 2003·Protein Expression and Purification·Jesús Rodríguez-DíazJavier Buesa
Nov 16, 2001·Microbes and Infection·O Lundgren, L Svensson
Aug 10, 2001·Current Opinion in Microbiology·M Ciarlet, M K Estes
Mar 6, 1999·Current Opinion in Microbiology·A A Lindberg
Feb 12, 2004·The Lancet Infectious Diseases·Evan J Anderson, Stephen G Weber
Feb 28, 2013·The British Journal of Nutrition·Shelly N HesterSharon M Donovan
Feb 13, 2008·Expert Reviews in Molecular Medicine·Richard L Ward
May 19, 1998·Nature Medicine·P J Sansonetti
Sep 11, 1999·Journal of Gastroenterology and Hepatology·R KatyalV Singh
Aug 17, 2000·The New England Journal of Medicine·E Salazar-LindoM Gutierrez
Feb 24, 2001·The New England Journal of Medicine·T V MurphyUNKNOWN Rotavirus Intussusception Investigation Team
Aug 15, 2009·The Journal of Biological Chemistry·Jiraporn OusingsawatKarl Kunzelmann
Aug 14, 2012·The Journal of Biological Chemistry·Rahul BhowmickMamta Chawla-Sarkar
Sep 28, 2006·The Journal of Biological Chemistry·René Barro SoriaKarl Kunzelmann
Apr 3, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A CascioS Arista
Jul 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M A de WitY T van Duynhoven
May 1, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Baoming JiangRoger I Glass

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.