Age-dependent differences in morphine-induced taste aversions

Developmental Psychobiology
Zachary E HurwitzAnthony L Riley

Abstract

Adolescence is a developmental period of particular importance given the host of neurobiological changes that occur during this stage of development. Drug use and abuse is said to be a function of the balance of its rewarding and aversive effects, and any age-dependent differences in morphine's aversive effects could impact drug intake. The present experiments examined the ability of morphine sulfate (0, 3.2, 10, and 18 mg/kg) to induce taste aversions in adolescent and adult rats under high (20-min fluid access each day; Experiment 1A/B) and low (50% of ad libitum access; Experiment 2A/B) deprivation conditions. In both studies, adolescent and adult rats were given a novel saccharin solution to drink and were subsequently injected with morphine. Independent of the deprivation condition, adults acquired stronger aversions than adolescents and did so at a faster rate. On a subsequent two-bottle aversion test, all morphine-injected subjects drank a significantly lower percentage of saccharin than vehicle-injected controls with adults exhibiting stronger aversions than adolescents. These age-dependent differences in morphine-induced CTAs extend the findings with other drugs of abuse for which adolescents exhibit weaker aversions. ...Continue Reading

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Citations

Apr 23, 2013·Psychopharmacology·Rachel I AndersonElena I Varlinskaya
Sep 30, 2014·Peptides·Richard J Bodnar
Oct 30, 2013·Developmental Psychobiology·Zachary E HurwitzAnthony L Riley
Oct 15, 2013·Developmental Psychobiology·Andrew P MerluzziAnthony L Riley
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Tamara L Doremus-Fitzwater, Linda P Spear
Mar 15, 2015·Behavioural Pharmacology·Nathan A Holtz, Marilyn E Carroll

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