Age-dependent differences in the efficacy of cancer immunotherapy in C57BL and AKR mouse strains

Experimental Gerontology
T KaptzanJ Leibovici

Abstract

While tumor incidence increases with age, tumor growth and metastasis often proceed at a slower rate in aged organisms. The mechanisms underlying this age-related reduced tumor development may suggest therapeutic modalities appropriate for the aged. Decreased tumor aggressiveness in the old was shown to be related to altered immune response. Consequently, the aim of the present study was to assess whether cancer immunotherapy has an age-dependent effect. Only a few studies have compared cancer immunotherapy efficiency as a function of age, most showing lower inhibition in older animals. In the present study, we tested the effect of two immunomodulators, levamisole and BCG, on two tumors, B16 melanoma and AKR lymphoma, in mice of different ages. We demonstrated a higher efficiency of immunotherapy in aged as compared to young mice, particularly at low immunomodulator doses. While decreased T cell function during aging is apparently established, nonspecific immunity is more preserved or even enhanced in later life. We found an increased number of macrophages in tumors of old compared to young mice and an increase in MAC-1+ cells in old levamisole-treated compared to non-treated mice. The stronger therapeutic effect of this immuno...Continue Reading

References

Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·N TakeichiH Kobayashi
Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·S P HoW B Ershler
Dec 1, 1987·Mechanisms of Ageing and Development·K Kawakami, E T Bloom
Nov 1, 1985·Mechanisms of Ageing and Development·H RabinowichA Klajman
Feb 1, 1973·American Journal of Surgery·C T CalabreseH Volk
Apr 1, 1972·Journal of Gerontology·I L Cameron
Sep 15, 1983·International Journal of Cancer. Journal International Du Cancer·C ChanyB Mace
Jul 1, 1984·Annales d'immunologie·D VaillierJ F Duplan
Nov 1, 1983·Journal of the American Geriatrics Society·W B ErshlerC J Greene
Jan 1, 1983·Experimental Gerontology·P EbbesenK Liestöl
Jan 1, 1995·Gerontology·I Dussault, S C Miller
May 12, 1995·Mechanisms of Ageing and Development·N DoninJ Leibovici
Oct 20, 1994·Mechanisms of Ageing and Development·E MarianiA Facchini
Jun 23, 1993·Annals of the New York Academy of Sciences·E S Kimball
Jan 1, 1994·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·M J HawkinsE Paietta
Nov 1, 1993·Diseases of the Colon and Rectum·N DaviesB A Taylor
Jul 5, 1996·Science·R A Miller
Jan 1, 1997·Experimental Gerontology·T TakedaK Higuchi
Jan 1, 1997·Experimental Gerontology·M HosonoT Hosokawa
Feb 10, 1999·Experimental Gerontology·S S Yen, G A Laughlin
Dec 5, 2002·Mutation Research·Lucia Migliore, Fabio Coppedè

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Citations

Nov 8, 2011·Immunotherapy·Judith LeiboviciJudith Sinai
Dec 24, 2008·Vaccine·David N PosnettAlan N Houghton
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Cynthia C SprengerMay J Reed
Feb 16, 2006·Mechanisms of Ageing and Development·Tatiana KaptzanJudith Leibovici
May 6, 2008·Mechanisms of Ageing and Development·Judith LeiboviciGinnette Schiby
Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·May J ReedStephen Plymate
May 13, 2020·GeroScience·Dushani L PalliyaguruRafael de Cabo
Jun 1, 2021·Frontiers in Oncology·Liese VandeborneGauthier Bouche

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