Age-dependent dose response to gentamicin.

The Journal of Pediatrics
P EcheverriaD Paed

Abstract

Serum gentamicin concentrations were measured 30 minutes after 140 intravenous doses in 60 children and nine adults with normal renal function. Distinct interpatient variation was observed but individual patients tended to have similar pharmacokinetics with repeated doses. Age had a significant effect in that mean peak serum concentrations were 1.58 mug/ml per 1 mg/kg dose in children between 6 months and 5 years, 2.03 mug/ml per 1 mg/kg in those between 5 and 10, and 2.86 mug/ml per 1 mg/kg in children 10 to 15 years of age. The mean calculated single dose of gentamicin necessary to achieve a peak serum concentration between 4 and 5 mug/ml is 2.5 mg/kg for ages 0.5 to 5 years, 2.0 mg/kg for ages 5 to 10 years, and 1.5 mg/kg for individuals over 10 years of age.

Citations

Nov 1, 1992·Equine Veterinary Journal·S L GreenJ D Baird
Jan 7, 1998·The Annals of Pharmacotherapy·J D Robinson
Feb 1, 1980·Archives of Disease in Childhood·G W Rylance, T A Moreland
Jan 1, 1980·European Journal of Pediatrics·R MarreK Sack
Jul 1, 1993·Equine Veterinary Journal·S L Green, P D Conlon
Apr 16, 2002·Journal of Child Neurology·Tracy A Glauser, John M Pellock
Nov 1, 1977·Archives of Disease in Childhood·B M AssaelF Sereni
Nov 1, 1979·British Journal of Clinical Pharmacology·N BuchananC Eyberg
Mar 13, 2015·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Hong Lu, Sara Rosenbaum
Sep 1, 1978·Antimicrobial Agents and Chemotherapy·N J MirhijM G Myers

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