Age-dependent effects of body mass index across the adult life span on the risk of dementia: a cohort study with a genetic approach

BMC Medicine
Ida K KarlssonAnna K Dahl Aslan

Abstract

While a high body mass index (BMI) in midlife is associated with higher risk of dementia, high BMI in late-life may be associated with lower risk. This study combined genetic designs with longitudinal data to achieve a better understanding of this paradox. We used longitudinal data from 22,156 individuals in the Swedish Twin Registry (STR) and 25,698 from the Health and Retirement Study (HRS). The STR sample had information about BMI from early adulthood through late-life, and the HRS sample from age 50 through late-life. Survival analysis was applied to investigate age-specific associations between BMI and dementia risk. To examine if the associations are influenced by genetic susceptibility to higher BMI, an interaction between BMI and a polygenic score for BMI (PGSBMI) was included in the models and results stratified into those with genetic predisposition to low, medium, and higher BMI. In the STR, co-twin control models were applied to adjust for familial factors beyond those captured by the PGSBMI. At age 35-49, 5 units higher BMI was associated with 15% (95% CI 7-24%) higher risk of dementia in the STR. There was a significant interaction (p = 0.04) between BMI and the PGSBMI, and the association present only among those...Continue Reading

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Citations

May 14, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Adina Zeki Al HazzouriKristine Yaffe
May 25, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Ida K KarlssonAnna K Dahl Aslan

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Methods Mentioned

BETA
genotyping

Software Mentioned

TwinGene
Plink

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