Age-Dependent Effects of Type I and Type III IFNs in the Pathogenesis of Bordetella pertussis Infection and Disease

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jeremy ArdanuyNicholas H Carbonetti

Abstract

Type I and III IFNs play diverse roles in bacterial infections, being protective for some but deleterious for others. Using RNA-sequencing transcriptomics we investigated lung gene expression responses to Bordetella pertussis infection in adult mice, revealing that type I and III IFN pathways may play an important role in promoting inflammatory responses. In B. pertussis-infected mice, lung type I/III IFN responses correlated with increased proinflammatory cytokine expression and with lung inflammatory pathology. In mutant mice with increased type I IFN receptor (IFNAR) signaling, B. pertussis infection exacerbated lung inflammatory pathology, whereas knockout mice with defects in type I IFN signaling had lower levels of lung inflammation than wild-type mice. Curiously, B. pertussis-infected IFNAR1 knockout mice had wild-type levels of lung inflammatory pathology. However, in response to infection these mice had increased levels of type III IFN expression, neutralization of which reduced lung inflammation. In support of this finding, B. pertussis-infected mice with a knockout mutation in the type III IFN receptor (IFNLR1) and double IFNAR1/IFNLR1 knockout mutant mice had reduced lung inflammatory pathology compared with that in...Continue Reading

References

Oct 4, 2003·Journal of Leukocyte Biology·Kate SchroderDavid A Hume
Oct 24, 2003·Infection and Immunity·Nicholas H CarbonettiZoe E V Worthington
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giovanna SchiavoniEnrico Proietti
Aug 11, 2004·The Journal of Experimental Medicine·Ryan M O'ConnellGenhong Cheng
Oct 28, 2005·Journal of Zhejiang University. Science. B·E GruysS J Koopmans
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chuan He YangLawrence M Pfeffer
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giuseppe MancusoGiuseppe Teti
May 9, 2007·The Journal of Experimental Medicine·Xiaoming ZhangRichard Lo-Man
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jiaying HuangSergei V Kotenko
Jul 5, 2007·Journal of Paediatrics and Child Health·Rebecca L SomervilleDiana Purvis
Jul 20, 2007·The Cochrane Database of Systematic Reviews·S AltunaijiJ Massie
Jan 18, 2008·European Journal of Immunology·Bénédicte DanisDominique De Wit
Jun 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christopher D PaddockSherif R Zaki
Jul 16, 2009·The Journal of Clinical Investigation·Francis J MartinAlice Prince
Aug 18, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Raymond P Donnelly, Sergei V Kotenko
May 18, 2011·Genes & Development·Aimée M Deaton, Adrian Bird
Dec 2, 2011·Annals of the New York Academy of Sciences·Yanick J Crow
Mar 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Su-Yang LiuGenhong Cheng
Mar 8, 2012·Growth Factors·Serge Y Fuchs
Sep 14, 2012·The New England Journal of Medicine·Nicola P KleinRoger Baxter
Oct 3, 2012·Infection and Immunity·Carey E ConnellyNicholas H Carbonetti
Nov 8, 2012·Protein & Cell·Musheng Bao, Yong-Jun Liu
Apr 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Alessandro MichelucciKarsten Hiller
Jun 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Poonam TewaryJoost J Oppenheim
Sep 24, 2013·JAK-STAT·Isabella RauchThomas Decker
Oct 26, 2013·International Immunology·Javier Antonio Carrero
Feb 1, 2014·EMBO Molecular Medicine·Sabyasachi BhattacharyaSerge Y Fuchs
Mar 15, 2014·The Journal of Infectious Diseases·Thomas A Clark
Sep 23, 2014·The Cochrane Database of Systematic Reviews·Kay WangAnthony Harnden
Dec 4, 2014·Nature Communications·Roberto LandeLoredana Frasca
Dec 30, 2014·The Journal of Infectious Diseases·Ciaran SkerryNicholas H Carbonetti
Jan 24, 2015·Nature Reviews. Immunology·Finlay McNabAnne O'Garra
Feb 26, 2015·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sophia DavidsonAndreas Wack
Jun 18, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kathleen WinterJames D Cherry
Jan 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·John R TeijaroHugh Rosen

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