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Age-dependent emergence of neurophysiological and behavioral abnormalities in progranulin-deficient mice

Alzheimer's Research & Therapy

Oct 22, 2019

Dávid NagyMihaly Hajos

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Abstract

Loss-of-function mutations in the progranulin gene cause frontotemporal dementia, a genetic, heterogeneous neurodegenerative disorder. Progranulin deficiency leads to extensive neuronal loss in the frontal and temporal lobes, altered synaptic connectivity, and behavioral alterations. Th...read more

Mentioned in this Paper

Mental Depression
Electrophysiology (Science)
Inflammation
Laboratory mice
Neurons
Temporal Lobe
Frontotemporal Dementia
Neurodegenerative Disorders
Murine
Gene Mutation
4
2
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Age-dependent emergence of neurophysiological and behavioral abnormalities in progranulin-deficient mice

Alzheimer's Research & Therapy

Oct 22, 2019

Dávid NagyMihaly Hajos

PMID: 31639062

DOI: 10.1186/s13195-019-0540-x

Abstract

Loss-of-function mutations in the progranulin gene cause frontotemporal dementia, a genetic, heterogeneous neurodegenerative disorder. Progranulin deficiency leads to extensive neuronal loss in the frontal and temporal lobes, altered synaptic connectivity, and behavioral alterations. Th...read more

Mentioned in this Paper

Mental Depression
Electrophysiology (Science)
Inflammation
Laboratory mice
Neurons
4
2

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