Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats

Neuroscience Journal
Evgenia SitnikovaAlexey A Koronovsky

Abstract

The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, the incidence of epileptic spike-wave discharges is known to be elevated with age. Considering close relationship between epileptic spike-wave discharges and physiologic sleep spindles, it was assumed that age-dependent increase of epileptic activity may affect time-frequency characteristics of sleep spindles. In order to examine this hypothesis, electroencephalograms (EEG) were recorded in WAG/Rij rats successively at the ages 5, 7, and 9 months. Spike-wave discharges and sleep spindles were detected in frontal EEG channel. Sleep spindles were identified automatically using wavelet-based algorithm. Instantaneous (localized in time) frequency of sleep spindles was determined using continuous wavelet transform of EEG signal, and intraspindle frequency dynamics were further examined. It was found that in 5-months-old rats epileptic activity has not fully developed (preclinical stage) and sleep spindles demonstrated an increase of instantaneous frequency from beginning to the end. At the age of 7 and 9 months, when animals developed matured and longer epileptic discharges (symptomatic stage), their sleep spindles did not display changes...Continue Reading

References

Sep 1, 1987·Epilepsy Research·A M Coenen, E L Van Luijtelaar
Sep 21, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G K Kostopoulos
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Mircea Steriade
Oct 24, 2003·Sleep Medicine Reviews·Luigi De Gennaro, Michele Ferrara
Oct 24, 2003·Behavior Genetics·A M L Coenen, E L J M Van Luijtelaar
Dec 13, 2006·Epilepsy Research·Gilles van Luijtelaar, Arthur Bikbaev
Oct 12, 2010·Journal of Neuroscience Methods·Alexey OvchinnikovGilles van Luijtelaar
Feb 5, 2011·Journal of Neuroscience Methods·Suzana V SchönwaldGünther J L Gerhardt
Aug 24, 2011·Pflügers Archiv : European journal of physiology·Nathalie LerescheVincenzo Crunelli
Dec 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas AndrillonItzhak Fried
Aug 1, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Diego Z CarvalhoSuzana V Schönwald
Nov 16, 2013·Brain Research·Evgenia SitnikovaAlexey A Koronovsky

❮ Previous
Next ❯

Citations

Feb 4, 2021·Biological Reviews of the Cambridge Philosophical Society·Ivaylo Borislavov Iotchev, Eniko Kubinyi
Jun 17, 2021·Clinical and Experimental Pharmacology & Physiology·Sabriye KaradenizliNurbay Ateş

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.