Age-dependent increase of memory B cell response to cytomegalovirus in healthy adults

Experimental Gerontology
Judith H Aberle, Elisabeth Puchhammer-Stöckl

Abstract

Human cytomegalovirus (HCMV) may play an important role in immune system aging, due to its ability to modulate the host immune system. A significant age-related increase has been demonstrated for HCMV-specific serum antibody levels but so far, no information exists whether and to which extent the magnitude of the HCMV-specific memory B cell response develops with increasing age. We examined the size of the HCMV-specific memory B cell response and assessed whether there are quantitative differences in HCMV-specific memory B cell numbers and serum antibody titers against HCMV in young and older persons. The quantities of HCMV-specific memory B cells were determined in 20 young (20-31 years) and 21 older (60-80 years) healthy volunteers by limiting dilution analysis. HCMV-specific antibody levels were analyzed by ELISA. Our study demonstrates that higher HCMV-specific plasma antibody levels correlated well with the numbers of circulating HCMV-specific memory B cells and were not due to a generally higher antibody production in these individuals. The magnitude of HCMV-specific memory B cell responses was significantly higher in the group of older as compared to young subjects, but showed a high degree of individual variation in eld...Continue Reading

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Citations

Feb 28, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Effrossyni Gkrania-KlotsasNicholas J Wareham
Feb 21, 2013·Experimental Gerontology·Benedikt SimonElisabeth Puchhammer-Stöckl
Jun 12, 2013·Canadian Journal of Physiology and Pharmacology·Thea MagroneMauro Serafini
Feb 3, 2016·Human Vaccines & Immunotherapeutics·Ursula WiedermannAngelika Wagner
Sep 17, 2013·Journal of Medical Virology·Benson OgunjimiPhilippe Beutels
Feb 1, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C Smith, R Khanna
Sep 1, 2012·Blood·Doron Melamed, David W Scott
Feb 6, 2016·IEEE Reviews in Biomedical Engineering·Ilario ImbintoChristian Cipriani
Jun 28, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer L YatesGary M Winslow
Aug 18, 2020·Annals of Medicine·Santiago González-QuijadaLorena Pérez-González
Sep 28, 2017·PLoS Computational Biology·Michiel van BovenDebbie van Baarle

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