Age-dependent kinetics of dentate gyrus neurogenesis in the absence of cyclin D2.

BMC Neuroscience
Anne AnsorgAnja Urbach

Abstract

Adult neurogenesis continuously adds new neurons to the dentate gyrus and the olfactory bulb. It involves the proliferation and subsequent differentiation of neuronal progenitors, and is thus closely linked to the cell cycle machinery. Cell cycle progression is governed by the successive expression, activation and degradation of regulatory proteins. Among them, D-type cyclins control the exit from the G1 phase of the cell cycle. Cyclin D2 (cD2) has been shown to be required for the generation of new neurons in the neurogenic niches of the adult brain. It is differentially expressed during hippocampal development, and adult cD2 knock out (cD2KO) mice virtually lack neurogenesis in the dentate gyrus and olfactory bulb. In the present study we examined the dynamics of postnatal and adult neurogenesis in the dentate gyrus (DG) of cD2KO mice. Animals were injected with bromodeoxyuridine at seven time points during the first 10 months of life and brains were immunohistochemically analyzed for their potential to generate new neurons. Compared to their WT litters, cD2KO mice had considerably reduced numbers of newly born granule cells during the postnatal period, with neurogenesis becoming virtually absent around postnatal day 28. This...Continue Reading

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Citations

Apr 9, 2013·Asian Journal of Andrology·Jianfeng XuS Lilly Zheng
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Jun 20, 2019·Frontiers in Cell and Developmental Biology·Aixa V Morales, Helena Mira

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Methods Mentioned

BETA
confocal laser

Software Mentioned

ImageJ

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