Age-dependent likelihood of in situ thrombosis in secondary pulmonary hypertension

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Lúcia H CaramuruAntonio Augusto Lopes

Abstract

Pulmonary arterial thrombosis (PAT) may complicate the clinical course of pulmonary hypertension associated with congenital heart disease (so-called Eisenmenger syndrome, ES). In this study, variables were sought that could represent risk factors for the occurrence of this complication. Twenty patients aged 11 to 53 (median, 33) years were studied. The presence of PAT (spiral computed tomography angiography) was correlated with age, gender group, PAP, hematocrit, peripheral oxygen saturation (SpO(2)), and plasma levels of endothelial and coagulation dysfunction markers: von Willebrand factor antigen (vWF:Ag), tissue plasminogen activator (t-PA), and D-dimer (enzyme immunoassay). Patients were classified according to the presence (group 1, N=7), or absence (group 2, N=13) of PAT. Group 1 patients were older (42+/-8 vs. 27+/-10 years in group 2, p=0.0051), had lower SpO(2) (82+/-7% vs. 89+/-6% in group 2, p=0.0462) and increased D-dimer levels (637 vs. 149 ng/mL in group 2, median values, p=0.0235). A trend was observed toward an increase in vWF:Ag (125+/-29 vs. 103+/-18 U/dL in group 2, p=0.0789) and t-PA (15.7 vs. 9.4 ng/mL in group 2, median values, p=0.0689). Age was the main variable influencing the occurrence of PAT in mult...Continue Reading

References

May 4, 1984·JAMA : the Journal of the American Medical Association·S Rich, B H Brundage
Oct 1, 1994·American Journal of Respiratory and Critical Care Medicine·K HuberB R Binder
Jul 1, 1994·International Journal of Cardiology·A SahaR Kutty
Aug 1, 1996·The American Journal of Medicine·P CacoubM C Boffa
May 1, 1997·Cardiovascular Research·M Rabinovitch
Dec 16, 1998·Annals of Internal Medicine·W VongpatanasinR A Lange
Sep 6, 2000·Nature Genetics·UNKNOWN International PPH ConsortiumR C Trembath
Nov 30, 2000·Current Treatment Options in Cardiovascular Medicine·S Rich
Feb 19, 2002·American Journal of Respiratory and Critical Care Medicine·Peter DorfmüllerMarc Humbert
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Karl BalabanianMarc Humbert
Nov 2, 2002·Progress in Cardiovascular Diseases·Erika Berman Berman, Robyn J Barst
Jan 9, 2003·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Antonio Augusto LopesNair Yukie Maeda
Sep 26, 2003·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Lúcia Helena CaramurúAntonio Augusto Lopes

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Citations

Jul 16, 2005·Hematology·Ari ZimranDeborah Elstein
Jul 22, 2015·Heart·George Giannakoulas, Maria Boutsikou
May 31, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Suma JainBen deBoisblanc
May 19, 2006·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Lúcia H CaramuruCyrillo Cavalheiro Filho
May 29, 2018·Journal of Thrombosis and Haemostasis : JTH·Barry KevaneFionnuala Ní Áinle
Sep 17, 2005·Cardiology in the Young·Rosangela de P S SoaresAntonio Augusto Lopes

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