PMID: 6104984Jun 20, 1980Paper

Age-dependent modifications in membrane lipids: lipid composition, fluidity and palmitoyl-CoA desaturase in Tetrahymena membranes

Biochimica Et Biophysica Acta
Y NozawaK Ohki

Abstract

The membrane lipid composition of Tetrahymena pyriformis NT-I was observed to change in a manner markedly dependent on the progress of culture age. The pellicular, mitochondrial and microsomal membranes were isolated from cell harvested at various growth phases (I, early exponential; II, mid-exponential; III, late exponential; IV, early stationary; V, late stationary) and their lipid composition was analyzed by thin-layer and gas-liquid chromatography. Although the phospholipid composition varied somewhat among membrane fractions, the most general age-dependent alteration was a considerable decrease in the content of phosphatidylethanolamine accompanied by a small increase in phosphatidylcholine. The 2-aminoethylphosphonolipid, enriched in the surface membrane pellicle, did not undergo a consistent change. As for fatty acid composition the most notable variation occurred in unsaturated fatty acids; a great increase in oleic and linoleic acids and a compensatory decrease in palmitoleic acid. This resulted in an augmented unsaturation of the overall phospholipid fatty acid profile of the aged membranes. The age-associated drastic decline in the palmitoleic acid content in membrane phospholipids could be accounted for by the marke...Continue Reading

References

May 31, 1977·Biochimica Et Biophysica Acta·G A Thompson, Y Nozawa
Jul 27, 1979·Biochimica Et Biophysica Acta·J T Bernert, H Sprecher
Apr 4, 1978·Biochimica Et Biophysica Acta·B D McKersieJ E Thompson
Jan 5, 1979·Biochimica Et Biophysica Acta·B D McKersie, J E Thompson
Nov 1, 1976·The Journal of Cell Biology·J Smith-Sonneborn, S R Rodermel
Sep 1, 1969·Chemistry and Physics of Lipids·A S WaggonerA D Keith
Feb 1, 1969·Journal of Bacteriology·S Rottem, S Razin
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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Citations

May 20, 2014·Cell Biochemistry and Biophysics·Gabriele BonaventuraEnrico Gratton
Jan 1, 1993·Progress in Lipid Research·J D Smith
Apr 1, 1986·Experimental Parasitology·D H BroniaS T Bertetto

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