Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease

Behavioral Neuroscience
Susanna PietropaoloBenjamin K Yee

Abstract

The triple-transgenic mouse line (3 x Tg-AD) harboring PS1M146V, APPSwe, and taup301L transgenes represents the only transgenic model for Alzheimer's disease (AD) to date capturing both beta-amyloid and tau neuropathology. The present study provides an extensive behavioral characterization of the 3 x Tg-AD mouse line, evaluating the emergence of noncognitive and cognitive AD-like symptoms at two ages corresponding to the early (6-7 months) and advanced (12-13 months) stages of AD-pathology. Enhanced responsiveness to aversive stimulation was detected in mutant mice at both ages: the 3 x Tg-AD genotype enhanced acoustic startle response and facilitated performance in the cued-version of the water maze. These noncognitive phenotypes were accompanied by hyperactivity and reduced locomotor habituation in the open field at the older age. Signs of cognitive aberrations were also detected at both ages, but they were limited to associative learning. The present study suggests that this popular transgenic mouse model of AD has clear phenotypes beyond the cognitive domain, and their potential relationship to the cognitive phenotypes should be further explored.

Citations

Jun 20, 2012·Molecular Neurodegeneration·Shaefali P RodgersJoanna L Jankowsky
Feb 5, 2014·Cognitive, Affective & Behavioral Neuroscience·Susanna PietropaoloBenjamin K Yee
Dec 15, 2010·Neuromolecular Medicine·Claudia Balducci, Gianluigi Forloni
May 1, 2015·Expert Opinion on Drug Discovery·Daniela PuzzoOttavio Arancio
Jun 30, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Tyler A Kokjohn, Alex E Roher
Jul 27, 2011·Biochemical Society Transactions·Lindsay Graham, Calum Sutherland
Jan 7, 2014·Behavioural Brain Research·Adi Shruster, Daniel Offen
Jan 23, 2015·The International Journal of Neuropsychopharmacology·Adele RomanoTommaso Cassano
Apr 22, 2015·Behavioural Brain Research·Kurt R StoverRichard E Brown
Apr 3, 2019·International Journal of Molecular Sciences·Jonathan IaconelliRakesh Karmacharya
Jun 26, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Milene VandalFrederic Calon
Sep 18, 2016·Journal of Molecular Neuroscience : MN·A ShepherdE L Burrows
Jul 13, 2019·International Journal of Molecular Sciences·Akira Nakajima, Yasushi Ohizumi
Feb 14, 2020·International Journal of Molecular Sciences·Ariel AngelDaniel Offen
Feb 20, 2020·Neuroscience and Biobehavioral Reviews·Filip KoselTamara B Franklin
Nov 6, 2017·Behavioural Brain Research·Lucas Ezequiel Serrano SpontonBenjamin K Yee
Oct 2, 2021·Scientific Reports·Yesica GloriaBenjamin B Tournier

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