Age-Dependent Presentation and Clinical Course of 1465 Patients Aged 0 to Less than 18 Years with Ovarian or Testicular Germ Cell Tumors; Data of the MAKEI 96 Protocol Revisited in the Light of Prenatal Germ Cell Biology

Cancers
G CalaminusU Göbel

Abstract

To evaluate prognostic factors in pediatric patients with gonadal germ cell tumors (GCT). Patients <18 years with ovarian and testicular GCT (respectively OGCT and TGCT) were prospectively registered according to the guidelines of MAKEI 96. After resection of the primary tumor, patients staged ≥II received risk-stratified cisplatin-based combination chemotherapy. Patients were analyzed in respect to age (six age groups divided into 3-year intervals), histology, stage, and therapy. The primary end point was overall survival. Between January 1996 and March 2016, the following patients were registered: 1047 OGCT, of those, 630 had ovarian teratoma (OTER) and 417 had malignant OGCT (MOGCT); and 418 TGCT, of those, 106 had testicular teratoma (TTER) and 312 had malignant TGCT (MTGCT). Only in MTGCT, older age correlated with a higher proportion of advanced tumors. All 736 teratomas and 240/415 stage I malignant gonadal GCT underwent surgery and close observation alone. In case of watchful waiting, the progression rate of OGCT was higher than that of TGCT. However, death from disease was reported in 8/417 (1.9%) MOGCT and 8/312 (2.6%) MTGCT irrespective of adjuvant chemotherapy and repeated surgery. The different pathogenesis and his...Continue Reading

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Citations

Oct 11, 2020·Cancers·Cezanne D KooijAnnelies M C Mavinkurve-Groothuis
Mar 7, 2021·Journal of Clinical Medicine·Christoph Wohlmuth, Iris Wohlmuth-Wieser
Mar 13, 2021·Rare Tumors·Yasser ElboraiOmar Alsharif
Aug 21, 2021·Seminars in Pediatric Surgery·Fuchs JWarmann Sw

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Methods Mentioned

BETA
chromosomal aberrations

Software Mentioned

Excel
MAKEI
SAS

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