Age-dependent reductions in mitochondrial respiration are exacerbated by calcium in the female rat heart.

Gender Medicine
J C HunterDonna H Korzick

Abstract

Cardiovascular disease mortality increases rapidly after menopause by poorly defined mechanisms. Because mitochondrial function and Ca(2+) sensitivity are important regulators of cell death after myocardial ischemia, we sought to determine whether aging and/or estrogen deficiency (ovariectomy) increased mitochondrial Ca(2+) sensitivity. Mitochondrial respiration was measured in ventricular mitochondria isolated from adult (6 months; n = 26) and aged (24 months; n = 25), intact or ovariectomized female rats using the substrates α-ketoglutarate/malate (complex I); succinate/rotenone (complex II); ascorbate/N,N,N',N'-tetramethyl-p-phenylenediamine/antimycin (complex IV). State 2 and 3 respiration was initiated by sequential addition of mitochondria and adenosine diphosphate. Ca(2+) sensitivity was assessed by Ca(2+)-induced swelling of de-energized mitochondria and reduction in state 3 respiration. Propylpyrazole triol (PPT) was administered intraperitoneally 45 minutes before euthanasia to assess mitochondrial protective effects through estrogen receptor (ER) α activation. Aging decreased the respiratory control index (RCI; state 3/state 2) for complexes I and II by 12% and 8%, respectively, independent of ovary status (P < 0.05)...Continue Reading

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Citations

Mar 26, 2013·Pflügers Archiv : European journal of physiology·Donna H Korzick, Timothy S Lancaster
Nov 23, 2016·The Journal of Endocrinology·Natalia PavónSalvador Uribe-Carvajal
May 26, 2017·Alcoholism, Clinical and Experimental Research·Alexandra M GarvinDonna H Korzick
Nov 1, 2017·Physiological Reports·Gregory P BartonGary Diffee
May 21, 2013·Reproductive Health Matters·Shireen J JejeebhoyK G Santhya
Jan 19, 2019·Journal of Exercise Rehabilitation·Mi-Hyun NoHyo-Bum Kwak
Oct 13, 2020·Frontiers in Physiology·Gayathri K NatarajanWai-Meng Kwok

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