PMID: 22827876Aug 1, 2012Paper

Age-dependent salt hypertension in Dahl rats: fifty years of research

Physiological Research
J ZichaJ Kunes

Abstract

Fifty years ago, Lewis K. Dahl has presented a new model of salt hypertension - salt-sensitive and salt-resistant Dahl rats. Twenty years later, John P. Rapp has published the first and so far the only comprehensive review on this rat model covering numerous aspects of pathophysiology and genetics of salt hypertension. When we summarized 25 years of our own research on Dahl/Rapp rats, we have realized the need to outline principal abnormalities of this model, to show their interactions at different levels of the organism and to highlight the ontogenetic aspects of salt hypertension development. Our attention was focused on some cellular aspects (cell membrane function, ion transport, cell calcium handling), intra- and extrarenal factors affecting renal function and/or renal injury, local and systemic effects of renin-angiotensin-aldosterone system, endothelial and smooth muscle changes responsible for abnormal vascular contraction or relaxation, altered balance between various vasoconstrictor and vasodilator systems in blood pressure maintenance as well as on the central nervous and peripheral mechanisms involved in the regulation of circulatory homeostasis. We also searched for the age-dependent impact of environmental and pha...Continue Reading

References

Jan 1, 1979·Biology of the Neonate·B S MisankoS Solomon
Dec 1, 1979·Metabolism: Clinical and Experimental·S Ayachi
Jun 8, 1977·Pflügers Archiv : European journal of physiology·H DlouháJ Zicha
Jan 1, 1978·The Journal of Physiology·M ClaretF Giraud
Apr 1, 1976·Journal of Applied Physiology·G M CherchovichJ Jelinek
Jan 1, 1992·The American Journal of Physiology·E P Gomez-SanchezD Thwaites
Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·N E Rowland, M J Fregly
Nov 1, 1991·The Journal of Clinical Investigation·P Y Chen, P W Sanders
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·J KunesJ Zicha
Dec 1, 1991·The American Journal of Physiology·T A KotchenN Blehschmidt
Apr 1, 1991·The American Journal of Physiology·C T Hawk, J A Schafer
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·E E Soltis, M J Katovich
Mar 1, 1991·Journal of Hypertension·E GrossmanD S Goldstein
Jul 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T IshimitsuT Sugimoto
Sep 1, 1991·The American Journal of Physiology·R J Roman, M Kaldunski
Oct 1, 1991·The American Journal of Physiology·M A BoegeholdG A Hedge
Nov 1, 1991·Hypertension·G M ReavenH Chang
Jan 1, 1991·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G M ReavenH Chang
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·A E John, F J Morich
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·J P StaschD Neuser
Apr 1, 1990·Hypertension·M A Boegehold, T A Kotchen
Apr 1, 1990·The American Journal of Physiology·B EngelmannB Roelofsen
Aug 1, 1986·Journal of Hypertension·J P RappM O Onwochei
Apr 1, 1988·The American Journal of Physiology·T H Steele, L Challoner-Hue

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Citations

Aug 31, 2020·Journal of Human Hypertension·Olga Balafa, Rigas G Kalaitzidis
Sep 24, 2019·American Journal of Physiology. Renal Physiology·John P Rapp, Michael R Garrett
Oct 15, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Oksana NikolaienkoAlexander Staruschenko
Feb 23, 2020·Biomolecules·Fieke TerstappenA Titia Lely
Jun 15, 2019·The Journal of Pharmacology and Experimental Therapeutics·Samuel O OdutolaEmmanuel M Awumey
Feb 14, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Ashley C JohnsonMichael R Garrett
Jul 20, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Amrita V PaiKathryn Sandberg
Jul 12, 2017·Journal of the American Society of Nephrology : JASN·Wenguang FengPaul W Sanders
Nov 27, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Frank T SpradleyJennifer S Pollock
Jul 23, 2013·Physiological Research·A PúzserováI Bernátová
Feb 22, 2017·Journal of the American Society of Nephrology : JASN·Wenguang FengPaul W Sanders
Feb 5, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paul M O'ConnorChunhua Jin
Apr 21, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Josef ZichaIvana Vaněčková
May 12, 2021·British Journal of Pharmacology·Yan WangRobert E Widdop
Jul 23, 2016·Hypertension·Fernando ElijovichUNKNOWN American Heart Association Professional and Public Education Committee of the Council on Hypertension; Council on Functional

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