PMID: 8602176Mar 26, 1996Paper

Age dependent selection against HPRT deficient T lymphocytes in the HPRT+/- heterozygous mouse

Mutation Research
W DeubelK Hempel

Abstract

The fraction of HPRT deficient T lymphocytes was measured in the HPRT +/- female mouse between birth and an age of about 2 years. The animals were the F1 offspring of the HPRT deficient strain 129MF1 and HPRT competent C57BL/6J-mice. T lymphocytes from spleen were cloned in vitro and HPRT deficient clones were detected by double-labeling with [3H]thymidine and [14C]hypoxanthine. During the first weeks of life the fraction of deficient lymphocytes sharply decreases from about 50% at birth to 10-30% at an age of 10 weeks. In adult animals the fraction of HPRT deficient T cells smoothly further decreases to values about 10% at 80-90 weeks. The equation gamma(t)=[0.547 x exp(-0.405 x t)] + [0.453 x exp(-0.0116 x t)] was found to be a good approximation of the time course of HPRT deficient cells in spleen; gamma(t) is the fraction of deficient cells per competent cell and t is the age of animals in weeks. It is postulated that the selection against HPRT deficient T lymphocytes is the consequence of the reduced proliferative capacity of HPRT deficient cells (=selection factor). The time course of the ratio of deficient cells can be described as a function of the proliferation rate of the HPRT competent T cells and this selection fact...Continue Reading

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Citations

Oct 12, 2000·Mutation Research·O J Sansom, A R Clarke
Jun 6, 2003·Mutation Research·Anane AidooRobert H Heflich
Dec 31, 1997·Mutation Research·A AidooD A Casciano
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·M YoshiokaB A Finette
Dec 1, 2004·Aging Cell·Kimberly J BaileySteven C Pruitt
Aug 6, 2005·Mutation Research·Iain B LambertGeorge R Douglas
Nov 17, 2007·Environmental and Molecular Mutagenesis·Sachin V BendreRobert H Heflich
Jan 1, 1997·Environmental and Molecular Mutagenesis·A D da Cruz, B W Glickman
Apr 18, 2008·Environmental and Molecular Mutagenesis·Irene M JonesDavid O Nelson
Oct 27, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Paul J DonovanDouglas A Powell

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