PMID: 6985662Jan 1, 1980Paper

Age-dependent sensitivity of the lamb ductus arteriosus to indomethacin and prostaglandins

The Journal of Pediatrics
Ronald I ClymanM A Heymann

Abstract

Endogenous prostaglandins inhibit the ability of the ductus arteriosus to contract in response to oxygen. We studied the effects of endogenous prostaglandins and indomethacin (an inhibitor of endogenous prostaglandin production) on isometric contraction of isolated rings of lamb ductus arteriosus from animals of different gestational ages (98 to 103 days and 136 to 147 days; term is 150 days). Rings from animals at about 100 days' gestation have a significantly larger indomethacin-induced contraction than rings from animals near term. The lamb ductus arteriosus forms two prostaglandins that relax the vessel: postaglandin E2 and prostacyclin. PGI2 was three orders of magnitude less potent than PGE2. Rings from the younger animals were significantly more sensitive to the relaxing action of PGE2 and PGI2 than were rings from animals near term. This increased sensitivity of immature animals to endogenous prostaglandins is consistent with the more potent effect of indomethacin on rings from immature animals. These observations are also consistent with the findings that preterm infants have an increased incidence of patent ductus arteriosus and that indomethacin can constrict the ductus arteriosus in preterm infants.

References

Nov 1, 1975·European Journal of Pharmacology·P M OlleyF Coceani
Feb 1, 1978·Pediatric Research·R I Clyman, A M Rudolph
Jan 1, 1978·Biology of the Neonate·R I ClymanA M Rudolph
Mar 25, 1977·Biochimica Et Biophysica Acta·C R Pace-Asciak, G Rangaraj
Nov 1, 1963·The Journal of Physiology·V KOVALCIK

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Citations

Jul 1, 1980·European Journal of Clinical Pharmacology·F CoceaniJ E Lock
Jan 1, 1982·Pediatric Cardiology·W A Neal, M D Mullett
Jan 1, 1984·Pediatric Cardiology·I A KashaniJ R Utley
Dec 12, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Edward M Dzialowski, Henry Greyner
Mar 6, 2004·Seminars in Neonatology : SN·Jonathan Wyllie
Sep 11, 2002·Cardiology in the Young·Norman H Silverman, Heather Silverman
Mar 1, 1982·Australian Paediatric Journal·E D BurnardP Grattan-Smith
Oct 19, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·B H SuC H Tsai
Mar 1, 1994·The Journal of Clinical Investigation·J R CharpieR C Webb
Sep 7, 2004·Journal of Perinatal Medicine·Gyula TálosiSándor Túri
Aug 30, 2008·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Pia AgrenEduardo Villamor
Nov 1, 1989·Baillière's Clinical Endocrinology and Metabolism·E BirkM A Heymann
Nov 24, 2007·The Journal of Pediatrics·Nancy ChorneRonald I Clyman
Jul 22, 2015·Congenital Heart Disease·Justin J ElhoffAndrew M Atz
Jul 15, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Henry Greyner, Edward M Dzialowski
Sep 29, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·P ValiF Ing
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H KajinoR I Clyman
Sep 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Henry Greyner, Edward M Dzialowski
Nov 24, 2020·Cardiology in the Young·Mariam ZaidiAmer Harky

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