PMID: 8938365Feb 1, 1996Paper

Age-dependent susceptibility to intraabdominal abscess formation

Journal of Pediatric Surgery
K P Lally, T K Stonum

Abstract

Infection remains a major cause of morbidity and mortality in the surgical neonate, with the risk of developing infectious complications decreasing as age increases. Developmental changes in the immune system, as well as transplacentally acquired immunity, likely play a role in this differential risk. The purpose of this study was to determine whether there is an age-related susceptibility to intraabdominal abscess formation. The authors used a mouse model in which the combination of an aerobe, anaerobe, and adjuvant routinely forms abscesses. Litters of at least six C57 BL/6 mice were used. The mice received 10(7) of Enterococcus faecalis and 10(7) Bacteroides distasonis or 10(7) B distasonis alone. The mice were given 8 microL/g of 50% wheat bran (40 mg/mL) and 50% bacteria. There were at least four litters for each experiment. Intraabdominal abscesses were counted after 7 days. Ten-day-old mice had an incidence of intraabdominal abscesses that was similar to that of the adults (81% v 91%). There was a significant decrease in intraperitoneal infection after 10 days, until weaning (37% and 38%; P < .05). The authors conclude that there are significant developmental changes in susceptibility to intraabdominal abscess formation,...Continue Reading

References

Nov 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·O D Rotstein
Jan 1, 1990·Journal of Pediatric Surgery·N Bhattacharyya, A M Kosloske
Feb 1, 1968·The Journal of Pediatrics·M AllansmithJ R Maloney
Sep 1, 1974·The Journal of Pediatrics·D C AndersonR D Feigin
Jul 1, 1995·Journal of Pediatric Surgery·J R HorwitzM M Ziegler

❮ Previous
Next ❯

Citations

Sep 8, 2000·Bulletin of Experimental Biology and Medicine·B A ParamonovV Y Chebotarev

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.