Age-dependent variation for inducibility of metallothionein genes in mouse liver by cadmium

Developmental Genetics
D J ThomasP C Huang

Abstract

Cadmium is a toxic metal that induces the expression of metallothionein genes in many tissues and that binds avidly to metallothionein, a soluble transition metal binding protein. The present study examined the temporal pattern and magnitude of accumulation of metallothionein mRNA in liver of C57BL/6J mice of various ages treated with cadmium. In adult female mice, accumulation was dependent on the dosage level of cadmium and related to the concentration of this metal in liver. The accumulation of metallothionein mRNA in liver depended on age at exposure to cadmium. Intraperitoneal administration of 2 mg of cadmium per kg provoked small increases (two- to threefold) in levels of metallothionein mRNA in livers of 7- and 14-day-old mice. In contrast, cadmium treatment of 28- and 56-day-old mice resulted in 12- to 19-fold increases in levels of metallothionein mRNA in liver with maximum increases occurring 3 to 4 hr after treatment. Because similar patterns for the accumulation of cadmium of liver were found in 7-, 28-, and 56-day-old mice, observed age-dependent differences in induction of metallothionein mRNA in liver were probably not due to differences in the accumulation of cadmium in this organ. Taken together, these data su...Continue Reading

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Citations

Mar 1, 1989·Mechanisms of Ageing and Development·D J ThomasW H Adler
Jun 19, 1998·Critical Reviews in Toxicology·E J O'Flaherty
Jan 10, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Anatoly V SkalnyAlexey A Tinkov
Jul 23, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Poul BjerregaardKnud Ladegaard Pedersen

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