Age-dependent variations of lysosomal enzymes in human liver

The Tohoku Journal of Experimental Medicine
R MinamiT Nakao

Abstract

The specific activities, the Km values, and the elution patterns on DEAE 52 and Sephadex G-150 columns of six lysosomal enzymes in human liver during development were studied. The levels of total beta-D-glucuronidase and N-acetyl-beta-D-glucosaminidase activities in childhood liver were higher than those in fetal liver. The Km values of beta-D-glucuronidase and beta-D-galactosidase in fetal liver were about ten times higher than those in childhood liver. The elution patterns on DEAE 52 of beta-D-glucuronidase and on Sephadex G-150 of alpha-D- and beta-D-galactosidases changed with aging. It is suggested that lysosomal enzymes related to degradation of gangliosides and glycosaminoglycans change during development.

References

Jul 15, 1998·Mechanisms of Ageing and Development·A Lityńska, M Przybyło
Mar 14, 2000·Mechanisms of Ageing and Development·M Przybyło, A Lityńska
Apr 1, 1982·Experimental Eye Research·S Hayasaka, T Shiono
Aug 1, 1981·The British Journal of Ophthalmology

Related Concepts

Beta-N-Acetylglucosaminidase
Sephadex G
Fetal Structures
Glycosaminoglycans
Beta-glucuronidase
Gestational Age
Gangliosides
Exo-beta-D-Glucuronidase
Lysosomes
N-acetyl-beta-D-glucosaminidase Measurement

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