Apr 21, 2020

Clearing-induced tissue shrinkage: Novel observation of a thickness size effect.

BioRxiv : the Preprint Server for Biology
R. C. M. VuldersP. J. van der Zaag


The use of clearing agents has provided new insights in various fields of medical research (developmental biology, neurology) by enabling examination of tissue architecture in 3D. One of the challenges is that clearing agents induce tissue shrinkage and the shrinkage rates reported in the literature are incoherent. Here, we report that the shrinkage for a widely-used clearing agent decreases significantly with increasing sample size, and report an analytical description.

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Mentioned in this Paper

Magnetic Resonance Imaging
Cerebral Tracts
Plant fiber
Thalamocortical Radiations
Cell Differentiation Process

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