Age differences in clinical manifestation and prognosis of thyroid eye disease

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Guy J Ben SimonRuth Huna-Baron

Abstract

To examine the clinical differences in manifestation, course, treatment, and prognosis of thyroid eye disease (TED) in patients younger than 40 years of age at diagnosis compared to older patients. Medical record review of 131 TED patients was performed. The patients were divided into two age groups, Group 1 ≤ 40 years (23 patients) and Group 2 > 40 years (108 patients). Younger patients had more eyelid retraction and proptosis at initial presentation, whereas older patients were more likely to have diplopia (P = 0.001). Acute inflammatory signs were more common in the Group 2 patients (P = 0.04). Corrected visual acuity was 20/20 and 20/25 in both groups. Optic neuropathy was diagnosed only in Group 2 patients (n = 12; 11 %), and it resolved after steroids or orbital decompression surgery in all cases. The mean follow-up time was 36 months (36 ± 7.7; 59.3 ± 5.8). Systemic steroid use, orbital surgery, and strabismus surgery were more common in Group 2 (P < 0.0001, P < 0.05 respectively). TED under the age of 40 years has different clinical features. In our group of younger patients, the clinical presentation was milder than in the older group with a higher rate of lid retraction and proptosis and lower rate of restrictive myop...Continue Reading

References

Nov 1, 1988·Ophthalmology·J M NeigelJ A Spinelli
Mar 1, 1988·Archives of Internal Medicine·R A NordykeA S Harada
Jan 27, 1993·JAMA : the Journal of the American Medical Association·M F Prummel, W M Wiersinga
Feb 1, 1993·Archives of Ophthalmology·D L KendlerJ Rootman
Mar 1, 1996·American Journal of Ophthalmology·G B BartleyC A Gorman
Jul 21, 1998·Thyroid : Official Journal of the American Thyroid Association·C A Gorman
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·A AllahabadiaJ A Franklyn
Jan 25, 2002·The British Journal of Ophthalmology·Alan A McNab
Mar 23, 2002·Ophthalmic Plastic and Reconstructive Surgery·Kimberly P CockerhamScott R Graner
Apr 4, 2002·Journal of Endocrinological Investigation·L E KimballN R Farid
Aug 11, 2006·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Guy J Ben SimonJohn D McCann
Sep 14, 2006·The Journal of Clinical Endocrinology and Metabolism·N ManjiJ A Franklyn
Oct 13, 2006·The British Journal of Ophthalmology·David McKeagUNKNOWN European Group on Graves' Orbitopathy (EUGOGO)
Feb 27, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Daniele SaverinoMarcello Bagnasco
Aug 22, 2007·Neuroimmunomodulation·Marcello BagnascoGiampaola Pesce
Jun 24, 2008·Current Eye Research·Ahmet HondurBerati Hasanreisoglu
Jul 19, 2008·The Kaohsiung Journal of Medical Sciences·Muh-Chiou LinLuo-Ping Ger
Nov 18, 2008·Thyroid : Official Journal of the American Thyroid Association·Shueh Lin LimAmir S Khir
Jan 19, 2010·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Ai KozakiMasahiko Ayaki
Feb 26, 2010·The New England Journal of Medicine·Rebecca S Bahn
Mar 2, 2010·International Ophthalmology·J EhaJ Pohlenz
Jul 18, 2014·Clinical Ophthalmology·Shaheen C KavoussiFlora Levin

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Citations

Sep 21, 2018·Ophthalmic Plastic and Reconstructive Surgery·Ashley A CampbellMichael Kazim
Dec 12, 2019·Ophthalmology and Therapy·Nickisa M Hodgson, Fatemeh Rajaii
Jan 3, 2020·Asia-Pacific Journal of Ophthalmology·Jiawei ZhaoTimothy J McCulley
Jul 7, 2020·European Journal of Ophthalmology·Mohammad Taher RajabiRobert A Goldberg
Jan 29, 2020·Asia-Pacific Journal of Ophthalmology·Jiawei ZhaoTimothy J McCulley
Jul 23, 2020·Journal of Binocular Vision and Ocular Motility·Mohammadreza AkbariMirataollah Salabati
Nov 16, 2016·Current Opinion in Otolaryngology & Head and Neck Surgery·Daniel Wehrmann, Jastin L Antisdel
Sep 4, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yun SuXianqun Fan

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