Age differences in default mode activity on easy and difficult spatial judgment tasks.

Frontiers in Human Neuroscience
Denise C ParkLucas J Jenkins

Abstract

The default network is a system of brain areas that are engaged when the mind is not involved in goal-directed activity. Most previous studies of age-related changes in default mode processing have used verbal tasks. We studied non-verbal spatial tasks that vary in difficulty. We presented old and young participants with two spatial judgment tasks: an easy categorical judgment and a more demanding coordinate judgment. We report that (a) Older adults show markedly less default network modulation than young on the demanding spatial task, but there is age equivalence on the easy task; (b) This Age x Task interaction is restricted to the default network: Brain areas that are deactivated by the tasks, but that are outside the default network, show no interaction; (c) Young adults exhibit significantly stronger functional connectivity among posterior regions of the default network compared with older adults, whereas older adults exhibit stronger connectivity between medial prefrontal cortex and other sites; and (d) The relationship of default activity to reaction time performance on the spatial tasks is mediated by age: in old adults, those who deactivate the default network most also perform best, whereas the opposite is true in you...Continue Reading

Citations

Sep 7, 2013·Brain Imaging and Behavior·Cheryl L Grady, Douglas D Garrett
Apr 29, 2014·Neurobiology of Aging·Jonas PerssonLars Nyberg
Dec 3, 2014·Brain Research·Cindy Lustig, Tiffany Jantz
Mar 19, 2016·Ageing Research Reviews·Motoaki Sugiura
Apr 7, 2015·NeuroImage. Clinical·Jennifer VannestJerzy P Szaflarski
Apr 14, 2016·Experimental Aging Research·James R HoustonDavid J Madden
Mar 26, 2013·Neurobiology of Aging·Ying-Hui ChouDavid J Madden
Aug 11, 2010·Neurobiology of Aging·Marcus MeinzerBruce Crosson
May 25, 2013·Journal of the American Academy of Child and Adolescent Psychiatry·Moriah E ThomasonJustin M Carré
Nov 28, 2012·Neuron·Daniel L SchacterKarl K Szpunar
Mar 22, 2014·Social Cognitive and Affective Neuroscience·Cristina SaverinoCheryl L Grady
Feb 22, 2012·Behavioural Brain Research·Ruchika Shaurya PrakashArthur F Kramer
Nov 25, 2011·Social Cognitive and Affective Neuroscience·Joshua O S GohDenise C Park
Jul 28, 2011·Neurobiology of Aging·Gary R Turner, R Nathan Spreng
Dec 3, 2014·Neuropsychologia·Cheryl L GradyEllen Bialystok
Dec 1, 2011·Cerebral Cortex·R Nathan Spreng, Daniel L Schacter
Mar 19, 2019·Frontiers in Aging Neuroscience·Claudine HabakOury Monchi
Jun 20, 2019·Frontiers in Aging Neuroscience·Bryant M DudaLawrence H Sweet

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