PMID: 8604919Dec 1, 1995Paper

Age differences in effects of hypothermic ischemia on endothelial and ventricular function

The Annals of Thoracic Surgery
T HiramatsuJ E Mayer

Abstract

Prior studies indicate that immature myocardium has a greater tolerance to ischemia. Prior studies from our laboratory have shown that impaired postischemic endothelial function was correlated with reduced ventricular contractility, and that coronary endothelium has an important role in ischemia and reperfusion injury in neonatal hearts. We examined the differences of endothelial function as well as ventricular function between immature and mature hearts in isolated blood-perfused lamb and sheep hearts after 2 hours of 15 degrees C cardioplegic ischemia. Three groups were defined according to age: neonatal ( < 1 week) hearts (n = 8), infant (1 month) hearts (n = 8), and adult (1 year) hearts (n = 6). Each of the three groups underwent a similar protocol including ischemic time, myocardial temperature, and cardioplegic solution. Based on earlier work, all had low perfusion pressures during the first 10 minutes of reperfusion. Thereafter the perfusion pressure was constant at 60 mm Hg in the neonatal hearts, 80 mm Hg in the infant hearts, and 100 mm Hg in the adult hearts to match the mean arterial pressure at each age in this species. At 30 minutes of reperfusion, the neonatal and infant hearts achieved significantly improved re...Continue Reading

Citations

Mar 30, 2006·American Heart Journal·Steven E LipshultzNader Rifai
Apr 22, 2009·The Annals of Thoracic Surgery·J Darcy O'BrienCamille L Hancock Friesen
Sep 2, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yongnan LiBingren Gao
Dec 1, 2017·General Thoracic and Cardiovascular Surgery·Yasutaka Hirata

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