Age Differences in Prefrontal Surface Area and Thickness in Middle Aged to Older Adults

Frontiers in Aging Neuroscience
Vonetta M DotsonAdam J Woods

Abstract

Age is associated with reductions in surface area and cortical thickness, particularly in prefrontal regions. There is also evidence of greater thickness in some regions at older ages. Non-linear age effects in some studies suggest that age may continue to impact brain structure in later decades of life, but relatively few studies have examined the impact of age on brain structure within middle-aged to older adults. We investigated age differences in prefrontal surface area and cortical thickness in healthy adults between the ages of 51 and 81 years. Participants received a structural 3-Tesla magnetic resonance imaging scan. Based on a priori hypotheses, primary analyses focused on surface area and cortical thickness in the dorsolateral prefrontal cortex, anterior cingulate cortex, and orbitofrontal cortex. We also performed exploratory vertex-wise analyses of surface area and cortical thickness across the entire cortex. We found that older age was associated with smaller surface area in the dorsolateral prefrontal and orbitofrontal cortices but greater cortical thickness in the dorsolateral prefrontal and anterior cingulate cortices. Vertex-wise analyses revealed smaller surface area in primarily frontal regions at older ages,...Continue Reading

References

Mar 3, 1998·Archives of Neurology·C E CoffeyR N Bryan
Jun 9, 1998·IEEE Transactions on Medical Imaging·J G SledA C Evans
Mar 6, 1999·Stroke; a Journal of Cerebral Circulation·C DeCarliD Carmelli
May 29, 2000·Trends in Cognitive Sciences·G BushM I Posner
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Jan 28, 2003·Nature Neuroscience·Elizabeth R SowellArthur W Toga
Sep 10, 2003·Archives of General Psychiatry·Gina R KuperbergBruce Fischl
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Apr 1, 2004·Cerebral Cortex·David H SalatBruce Fischl
Oct 27, 2004·NeuroImage·Bruce FischlAnders M Dale
Aug 27, 2005·Human Brain Mapping·E LudersA W Toga
Jun 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bogdan DraganskiArne May
Aug 1, 2006·Journal of Magnetic Resonance Imaging : JMRI·Christoph PreulGabriele Lohmann
Aug 22, 2006·Neuroscience and Biobehavioral Reviews·Naftali Raz, Karen M Rodrigue
Mar 14, 2007·Brain : a Journal of Neurology·An-Tao DuMichael W Weiner
Apr 7, 2007·Annals of the New York Academy of Sciences·Naftali RazE Mark Haacke
Apr 13, 2007·IEEE Transactions on Medical Imaging·Florent SégonneBruce Fischl
Jan 15, 2008·Cognitive, Affective & Behavioral Neuroscience·Michael I PosnerYiyuan Tang
Jan 20, 2009·Cerebral Cortex·Anders M FjellKristine B Walhovd
Mar 21, 2009·Cerebral Cortex·Matthew S PanizzonWilliam S Kremen
Apr 22, 2009·Trends in Neurosciences·Pasko RakicMartin H Dominguez
Sep 19, 2009·Nature Reviews. Neuroscience·Pasko Rakic
Sep 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ylva OstbyKristine B Walhovd
Nov 28, 2009·Brain and Cognition·Tonya WhiteGuillermo Sapiro
Dec 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anders M FjellAnders M Dale

❮ Previous
Next ❯

Citations

Jan 13, 2018·Frontiers in Aging Neuroscience·Sahil BajajWilliam D S Killgore
Aug 28, 2020·Aging·Alexander SeilerRené-Maxime Gracien
Mar 28, 2019·Frontiers in Aging Neuroscience·Daiana R PurSandrine de Ribaupierre
Jan 20, 2017·Frontiers in Aging Neuroscience·Nicole R NissimAdam J Woods
Jan 6, 2021·Journal of Neuroengineering and Rehabilitation·Hanna LuUNKNOWN Open Access Series of Imaging Studies
Jul 14, 2021·Current Psychiatry Reports·Shawn M McClintockVonetta M Dotson

❮ Previous
Next ❯

Software Mentioned

SAS
Freesurfer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.