Age Differentiation within Gray Matter, White Matter, and between Memory and White Matter in an Adult Life Span Cohort.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Susanne M M de MooijRogier A Kievit

Abstract

It is well established that brain structures and cognitive functions change across the life span. A long-standing hypothesis called "age differentiation" additionally posits that the relations between cognitive functions also change with age. To date, however, evidence for age-related differentiation is mixed, and no study has examined differentiation of the relationship between brain and cognition. Here we use multigroup structural equation models (SEMs) and SEM trees to study differences within and between brain and cognition across the adult life span (18-88 years) in a large (N > 646, closely matched across sexes), population-derived sample of healthy human adults from the Cambridge Centre for Ageing and Neuroscience (www.cam-can.org). After factor analyses of gray matter volume (from T1- and T2-weighted MRI) and white matter organization (fractional anisotropy from diffusion-weighted MRI), we found evidence for the differentiation of gray and white matter, such that the covariance between brain factors decreased with age. However, we found no evidence for age differentiation among fluid intelligence, language, and memory, suggesting a relatively stable covariance pattern among cognitive factors. Finally, we observed a spec...Continue Reading

Citations

Jun 19, 2019·Cerebral Cortex·Delia FuhrmannRogier A Kievit
Jun 14, 2019·Reviews in the Neurosciences·Jessica OschwaldSusan Mérillat
Oct 9, 2019·Journal of Aging and Health·Meredith A ShaftoLorraine K Tyler
Aug 30, 2019·Advances in Methods and Practices in Psychological Science·Ross JacobucciRogier A Kievit
May 29, 2020·Psychonomic Bulletin & Review·John A E AndersonJohn G Grundy
Feb 14, 2021·Journal of Vestibular Research : Equilibrium & Orientation·E AnsonY Agrawal
Feb 16, 2021·Frontiers in Psychology·Manuel ArnoldAndreas M Brandmaier
Mar 11, 2021·Network Neuroscience·Erik-Jan van Kesteren, Rogier A Kievit
Oct 14, 2020·Neurobiology of Aging·Andrew J CarradusChristopher R Madan
Aug 1, 2021·Neurobiology of Aging·Jenna L MerensteinIlana J Bennett

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Software Mentioned

MGCFA
OpenMx package
Cam
LOSEM
CAN
R
SEM Trees
lavaan

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