Age distribution of paediatric rotavirus gastroenteritis cases in Europe: the REVEAL study

Scandinavian Journal of Infectious Diseases
Carlo GiaquintoREVEAL Study Group

Abstract

Rotavirus is the most frequent cause of severe diarrhoea in children aged <5 y. A prospective, multicentre, observational study was conducted in Europe during the 2004-2005 rotavirus season. The study was undertaken in areas of Belgium, France, Germany, Italy, Spain, Sweden, and the UK, to estimate the incidence of community-acquired acute gastroenteritis (AGE) and rotavirus gastroenteritis (RVGE) in children under 5 y of age seeking medical care in 3 settings: primary care, emergency department, and hospital. A post-hoc analysis was done to further describe the age distribution of children with RVGE. The study included 2846 children with AGE. Of 2712 children for whom ELISA results were available, 1102 (40.6%) were rotavirus-positive to the results section well. Overall, 86.1% of RVGE cases occurred in children aged between 3 months and 3 y, whereas 1.8% of cases were observed in infants aged less than 3 months. A total of 3.6% of cases occurred in children aged more than 4 y. These results suggest that, in Europe, routine vaccination for rotavirus should be offered to all infants in early childhood to be effective during the main at-risk period. This could significantly reduce the substantial burden of this potentially seriou...Continue Reading

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Citations

Feb 2, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D ValentiniA Villani
Jan 13, 2011·The Pediatric Infectious Disease Journal·Tessa BraeckmanPierre Van Damme
Nov 4, 2010·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Greg L Plosker
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Nov 27, 2014·Human Vaccines & Immunotherapeutics·Mohammad HowidiRodrigo DeAntonio
Aug 23, 2016·Clinical and Experimental Immunology·F ZibernaT Not
Jun 10, 2011·Memórias do Instituto Oswaldo Cruz·Sarah Cristina Fontes VieiraLuis E Cuevas
Feb 3, 2018·Human Vaccines & Immunotherapeutics·Alejandro Orrico-SánchezJavier Díez-Domingo
Dec 25, 2019·Archives of Disease in Childhood·Charlotte Mary GowerShamez Ladhani
Apr 19, 2020·American Journal of Infection Control·Ernestina Azor-MartinezFrancisco Gimenez-Sanchez
Jan 6, 2021·The Pediatric Infectious Disease Journal·Tone BruunUNKNOWN Norwegian Enhanced Pediatric Immunisation Surveillance Network
Mar 15, 2015·Open Access Macedonian Journal of Medical Sciences·Hala G ElnadyAhmed N El-Taweel
May 28, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Charlotte M GowerShamez N Ladhani

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