Age, gender, and hemispheric differences in iron deposition in the human brain: an in vivo MRI study

NeuroImage
Xiaojun XuMinming Zhang

Abstract

It is well known that iron accumulates in the brains of patients with various neurodegenerative diseases. To better understand disease-related iron changes, it is necessary to know the physiological distribution and accumulation of iron in the human brain. Studies have shown that brain iron levels increase with aging. However, the effects of gender and hemispheric laterality on iron accumulation and distribution are not well established. In this study, we estimated the brain iron levels in vivo in 78 healthy adults ranging in age 22 to 78 years using magnetic susceptibility-weighted phase imaging. The effects of age, gender, and hemispheric location on brain iron levels were evaluated within the framework of a general linear model. We found that the left hemisphere had higher iron levels than the right in the putamen, globus pallidus, substantia nigra, thalamus, and frontal white matter. We argue that the hemispheric asymmetry of iron content may underlie that of the dopaminergic system and may be related to motor lateralization in humans. In addition, significant age-related iron accumulation occurred in the putamen, red nucleus, and frontal white matter, but no gender-related differences in iron levels were detected. The resu...Continue Reading

Citations

Mar 1, 2012·Journal of Neural Transmission·P Riederer, J Sian-Hülsmann
Sep 14, 2012·Journal of Neural Transmission·Dominic J HarePeter Riederer
Jan 15, 2013·Metabolic Brain Disease·T LitwinR Poniatowska
May 27, 2010·Brain Imaging and Behavior·Stephen CorreiaBenjamin D Greenberg
Nov 13, 2009·Biological Trace Element Research·Setsuko TohnoYoshiyuki Tohno
Nov 1, 2012·Biological Trace Element Research·Yoshiyuki TohnoPasuk Mahakkanukrauh
Oct 1, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Patrícia RamosAgostinho Almeida
Jun 11, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erik K KastmanSterling C Johnson
Jan 15, 2011·International Journal of Alzheimer's Disease·Gabriela A SalvadorNorma M Giusto
Sep 17, 2010·Radiology·Christian LangkammerStefan Ropele
Jun 26, 2014·Biological Trace Element Research·Wei-Na KongShu-E Zhao
Aug 15, 2014·Biological Trace Element Research·Patrícia RamosAgostinho Almeida
Mar 31, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Huijun ChenChris D Vulpe
Dec 15, 2012·Expert Review of Neurotherapeutics·Jesper HagemeierRobert Zivadinov
Nov 1, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S ReimãoJ J Ferreira
Jan 26, 2013·Magnetic Resonance Imaging·Francesca BagnatoEdward Brian Welch
Nov 17, 2015·Journal of Computer Assisted Tomography·Dan WangHe Wang
Jun 19, 2012·Seminars in Pediatric Neurology·Giovanna ZorziNardo Nardocci
Jan 24, 2012·Neurobiology of Disease·Petr DusekWeidong Le
Sep 16, 2011·Journal of the Neurological Sciences·T LitwinA Członkowska
Aug 1, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Zsuzsanna AschermannPeter Bogner
Feb 9, 2010·Experimental Gerontology·Rafael Luiz RechNadja Schröder
Dec 24, 2015·Journal of Magnetic Resonance Imaging : JMRI·Manju LiuE Mark Haacke
Dec 10, 2008·Neuroimaging Clinics of North America·A L MacKayC Laule
Sep 26, 2008·Magnetic Resonance Imaging·Cristina RossiFritz Schick
Aug 30, 2014·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Taha M MehemedKaori Togashi
Mar 8, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Eva Alonso-OrtizG Bruce Pike
Jul 25, 2009·Journal of Magnetic Resonance Imaging : JMRI·Yiping P DuJody Tanabe

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