Age, hypertension, and cardiac responses to beta-agonist in humans

Clinical Pharmacology and Therapeutics
M WhiteF H Leenen

Abstract

To evaluate the effects of hypertension on heart rate and left ventricular responses to beta-agonist in young and older subjects, as well as the modulating effect of the arterial baroreflex on these responses. Isoproterenol (INN, isoprenaline) alone was infused in 14 young normotensive subjects (mean age, 30 +/- 2 years), 18 older normotensive subjects (mean age, 60 +/- 2 years), 11 young hypertensive subjects (mean age, 36 +/- 1 years), and 17 older hypertensive subjects (mean age, 59 +/- 1 years); isoproterenol combined with ganglionic blockade (trimethaphan [INN, trimetaphan]) was administered to eight young normotensive subjects and eight young hypertensive subjects. Isoproterenol was infused at three to four incremental rates, each rate for 8 minutes. Left ventricular responses were assessed by echocardiography. Isoproterenol caused similar increases in heart rate in all four groups. With ganglionic blockade, heart rate responses were enhanced but were similar in the young normotensive and hypertensive subjects. In young subjects, hypertension did not affect left ventricular responses to isoproterenol alone, whereas older hypertensive subjects showed some blunting of left ventricular responses compared with older normotens...Continue Reading

References

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Citations

Oct 7, 2004·European Journal of Pharmacology·Otto-Erich Brodde, Kirsten Leineweber
Mar 18, 2000·Hypertension·S JuliusP Palatini
Jan 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Frans H H LeenenRoselyn White
Feb 20, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Frans H H LeenenRoselyn White

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