Age-modification of lipoprotein, lipid, and lipoprotein ratio-associated risk for coronary artery calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA]).

The American Journal of Cardiology
Pathmaja ParamsothyKevin D O'Brien

Abstract

Although abnormal lipoproteins and lipoprotein ratios are powerful risk factors for clinical cardiovascular events, these associations are stronger in younger than in older subjects. Whether age modifies the relation of lipoproteins and lipoprotein ratios to the relative risk of subclinical cardiovascular disease (CVD), as assessed by coronary artery calcium (CAC) scores, has not been examined in a contemporary, multiethnic cohort. We performed multivariate relative risk regression analyses to determine the relative risks for associations of lipoproteins and lipoprotein ratios with prevalent CAC in participants in Multi-Ethnic Study of Atherosclerosis (MESA). The participants were community-dwelling adults aged 45 to 84 years without clinically apparent CVD at baseline. We excluded those taking lipid-lowering therapy (15%) and stratified the results by decades of age. A total of 5,092 participants met the inclusion criteria. In the fully adjusted models, per SD of low-density lipoprotein, the age-stratified, adjusted relative risk for CAC was 1.17 (95% confidence interval [CI] 1.07 to 1.28) for those aged 45 to 84 years but was 1.05 (95% CI 1.01 to 1.10) for those aged 75 to 84 years (p-interaction = 0.12). The relative risk pe...Continue Reading

References

Oct 25, 2002·American Journal of Epidemiology·Diane E BildRussell P Tracy
Nov 19, 2003·Annals of Internal Medicine·Tracey McLaughlinGerald Reaven
Apr 3, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Paolo RaggiLeslee J Shaw
Apr 23, 2004·American Journal of Physiology. Endocrinology and Metabolism·Radhika Vattikuti, Dwight A Towler
Jun 29, 2004·Biochemical and Biophysical Research Communications·Clarissa ColaJawahar L Mehta
Sep 24, 2004·Annals of Epidemiology·Emmanuel A Anum, Tilahun Adera
Apr 29, 2005·Radiology·Jennifer Clark NelsonRobert Detrano
Aug 2, 2005·The American Journal of Cardiology·Tracey McLaughlinRonald M Krauss
Feb 2, 2006·Heart·E S HouslayUNKNOWN Scottish Aortic Stenosis and Lipid Lowering Therapy, Impact on Regression trial Investigators
Apr 25, 2006·Journal of the American College of Cardiology·Renu VirmaniFrank D Kolodgie
Sep 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yuliya VengrenyukSheldon Weinbaum
May 22, 2007·Journal of the American College of Cardiology·Catherine M LoriaRobert Detrano
Mar 28, 2008·The New England Journal of Medicine·Robert DetranoRichard A Kronmal
Jun 4, 2008·Circulation·Linda L Demer, Yin Tintut
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos
Jun 27, 2009·Journal of the American College of Cardiology·Sadako MotoyamaJagat Narula
Feb 18, 2010·Journal of Cardiovascular Computed Tomography·Khurram NasirMatthew J Budoff

❮ Previous
Next ❯

Citations

Nov 17, 2011·Current Atherosclerosis Reports·Dipan A DesaiPamela Ouyang
Jul 9, 2011·International Journal of Epidemiology·George C M Siontis, John P A Ioannidis
Nov 13, 2012·Journal of the American College of Cardiology·Connie W TsaoChristopher J O'Donnell
Aug 3, 2014·The Canadian Journal of Cardiology·Patrick Mathieu, Marie-Chloé Boulanger
Apr 14, 2012·JACC. Cardiovascular Imaging·Jason C Kovacic, Valentin Fuster
May 25, 2013·Atherosclerosis·Raimund ErbelUNKNOWN Heinz Nixdorf Recall Study Investigators
Jun 8, 2014·Aging Clinical and Experimental Research·Wladimir M FreitasUNKNOWN Brazilian Study on Healthy Aging
Oct 4, 2012·The Annals of Pharmacotherapy·Matthew K Ito
Jul 26, 2021·Journal of Lipid Research·Samar R El KhoudaryDaniel J Rader

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.