Age modulates the effect of COMT genotype on delay discounting behavior.

Psychopharmacology
Christopher T Smith, Charlotte A Boettiger

Abstract

A form of impulsivity, the tendency to choose immediate over delayed rewards (delay-discounting) has been associated with a single nucleotide polymorphism (SNP) in the catechol-O-methyltransferase (COMT) gene (COMTval¹⁵⁸met; rs4680). However, the existing data regarding the nature of this association are in conflict. We have previously reported that adults homozygous for valine (val) at the COMTval¹⁵⁸met SNP demonstrate greater delay-discounting than do methionine (met) allele carriers (Boettiger et al., J Neurosci 27:14383-14391, 2007). In contrast, a recent study of adolescent males found that those with the met/met genotype demonstrate greater delay-discounting than do val-allele carriers (Paloyelis et al., Neuropsychopharmacology 35:2414-2426, 2010). Based on reported age-related changes in frontal dopamine function and COMT expression, we hypothesized that the association of COMT genotype with delay-discounting behavior is modulated by age from late adolescence to young adulthood. To test this hypothesis, we genotyped late adolescents (18-21 years; n = 72) and adults (22-40 years; n = 70) for the COMTval¹⁵⁸met polymorphism, measured their delay-discounting behavior, and tested for an interaction between age group and COMT ...Continue Reading

References

Jan 1, 1988·Journal of the Experimental Analysis of Behavior·J E Mazur
Jan 1, 1997·Journal of Psychopharmacology·A F Arnsten
Nov 5, 1997·Advances in Pharmacology·P S Goldman-Rakic
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·J A GogosM Karayiorgou
Aug 26, 1998·Behavioural Brain Research·T SagvoldenD Berger
Nov 7, 1999·Psychopharmacology·J L Evenden
Mar 17, 2000·Brain Research. Brain Research Reviews·P S Goldman-RakicG V Williams
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nitin GogtayPaul M Thompson
Jun 11, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·E M TunbridgeP J Harrison
Jul 15, 2004·Annals of the New York Academy of Sciences·Jay N Giedd
Aug 12, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert M BilderAnthony A Grace
Sep 16, 2004·Psychological Bulletin·Leonard Green, Joel Myerson
Nov 13, 2004·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Roshan Cools, Trevor W Robbins
May 20, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giuseppe BlasiDaniel R Weinberger
Dec 31, 2005·Alcoholism, Clinical and Experimental Research·Jennifer M MitchellCharlotte A Boettiger
Feb 16, 2006·Biological Psychiatry·Elizabeth M TunbridgeDaniel R Weinberger
Mar 1, 2006·Clinical Psychology Review·Catharine A WinstanleyTrevor W Robbins
May 30, 2006·Biological Psychiatry·Georg WintererDaniel R Weinberger
Aug 4, 2006·NeuroImage·Georg WintererDaniel R Weinberger
Aug 5, 2006·Neuroscience and Biobehavioral Reviews·Rhoshel K Lenroot, Jay N Giedd
Oct 19, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer M MitchellCharlotte A Boettiger
Jan 12, 2007·Behavioral and Brain Functions : BBF·Dan T A EisenbergDavid S Wilson
Sep 21, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Leonid YavichPekka T Männistö
Dec 7, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hao-Yang TanJoseph H Callicott
Dec 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Charlotte A BoettigerHoward L Fields
Mar 15, 2008·Biological Psychiatry·Jennifer H BarnettMarcus R Munafò
Mar 28, 2008·Nature Neuroscience·Kenji Doya
Aug 1, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shunsuke Kobayashi, Wolfram Schultz
Nov 26, 2008·Behavioral and Brain Functions : BBF·Melanie J WhiteRoss McD Young
Jul 1, 2009·Journal of the American Academy of Child and Adolescent Psychiatry·Yannis PaloyelisJonna Kuntsi
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Buyean LeeMark A Mandelkern

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Citations

Jan 23, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Margaret C WardleMarcus R Munafò
Jul 31, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew S KayserMichael J Frank
Oct 11, 2016·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Jacob N S Jackson, James MacKillop
Sep 15, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jonathan L HessStephen J Glatt
Dec 5, 2015·Frontiers in Human Neuroscience·Christopher T SmithCharlotte A Boettiger
Aug 19, 2015·Psychiatry Research·Bariş O Yildirim, Jan J L Derksen
Feb 1, 2015·Pharmacology, Biochemistry, and Behavior·Mary Katherine Kelm, Charlotte Ann Boettiger
Oct 26, 2016·Journal of Cognitive Neuroscience·Amanda EltonCharlotte A Boettiger
Feb 23, 2017·Cognitive, Affective & Behavioral Neuroscience·Narun PornpattananangkulRobin Nusslock
Dec 23, 2017·Frontiers in Human Neuroscience·Amanda EltonCharlotte A Boettiger
Sep 17, 2020·Attention, Perception & Psychophysics·Kristin N MeyerJoseph B Hopfinger
Jan 25, 2020·Perspectives on Behavior Science·Suzanne H Mitchell
Jun 10, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Annabelle M BelcherLuana Colloca
Aug 20, 2021·Neuroscience and Biobehavioral Reviews·Jai CarmichaelJennie Ponsford

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