Age of introduction of first complementary feeding for infants: a systematic review

BMC Pediatrics
Wafaa QasemJames Friel

Abstract

Despite a World Health Organization recommendation for exclusive breastfeeding of all full-term infants to 6 months of age, it is not clear what the health implications may be. Breast milk alone may not meet the nutrition needs for all growing infants, leaving them at risk for deficiencies. The objective of this study was to investigate the relationship between moderate (4 months) versus late (6 months) introduction of complementary foods to the full-term breastfed infant on iron status and growth. An electronic search of peer-reviewed and gray-literature was conducted for randomized control trials (RCTs) and observational studies related to the timing of introduction of complementary foods. Iron status and growth data from the relevant RCTs were analyzed using RevMan 5.2.11. Three RCTs and one observational study met the inclusion criteria. Meta-analysis showed significantly higher hemoglobin levels in infants fed solids at 4 months versus those fed solids at 6 months in developing countries [mean difference [MD]: 5.0 g/L; 95% CI: 1.5, 8.5 g/L; P = 0.005]. Meta-analysis also showed higher serum ferritin levels in the 4-month group in both developed and developing countries [MD: 26.0 μg/L; 95% CI: -0.1, 52.1 μg/L, P = 0.050], [...Continue Reading

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Citations

Oct 18, 2016·The Medical Clinics of North America·Mark R CorkinsSarah Jane Schwarzenberg
Oct 18, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Bernadeta Patro-GołąbHania Szajewska
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Jul 5, 2016·Annals of Laboratory Medicine·Hye Ryun LeeJu Young Chang
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Jan 30, 2020·Food Science & Nutrition·Jiali Zhang, Weiming Tang
Jan 18, 2020·Nutrients·Chiao-Ming ChenSing-Chung Li
Aug 7, 2021·BMC Public Health·Renata Oliveira NevesJuliana Rombaldi Bernardi

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Software Mentioned

Review Manager
RevMan
Cochrane Risk of Bias Tool

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