PMID: 3228590Dec 1, 1988Paper

Age-of-onset heterogeneity in hereditary breast cancer: minimal clues for diagnosis

Breast Cancer Research and Treatment
H T LynchJ Lynch

Abstract

Knowledge of the family history of cancer may significantly influence diagnosis and surgical management. Hereditary breast cancer (HBC) is common and accounts for approximately 9% of the total breast cancer burden. The pattern of HBC's natural history, including age of onset, increased incidence of bilaterality, integral tumor combinations in certain kindreds, and vertical transmission consonant with an autosomal dominantly inherited factor, when observed in context with the family history, enables pattern recognition so that the diagnosis might be facilitated. We describe seven families from our Hereditary Cancer Consultation Center (HCCC) and the Creighton Oncology Clinic which are noteworthy for extraordinarily early age of onset. This appears to be an additional example of heterogeneity in HBC and may represent the first account of this remarkable subset. The manner in which age of onset can be incorporated with other aspects of natural history for expediting diagnosis is discussed.

References

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Mar 11, 1988·JAMA : the Journal of the American Medical Association·D M EddyW Hendee
Jul 1, 1988·Breast Cancer Research and Treatment·H T LynchJ Lynch
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Citations

May 1, 1995·Breast Cancer Research and Treatment·A Lindblom
Feb 1, 1990·Breast Cancer Research and Treatment·H T LynchJ F Lynch
Jan 1, 1993·Breast Cancer Research and Treatment·A LindblomL Iselius
Feb 16, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H Van den Berghe, P Dal Cin
Nov 14, 1997·Patient Education and Counseling·C J Cornelisse, P Devilee
Sep 3, 1999·Breast Cancer Research and Treatment·A D PatersonT A Sellers
Jan 1, 1989·Chronobiology International·H W Simpson, K Griffiths
Jan 1, 1992·Acta Oncologica·A L Børresen
Nov 1, 1991·Journal of the American Geriatrics Society·L BalducciG H Lyman
Mar 15, 1992·Cancer·H T LynchJ F Lynch
Jun 1, 1990·Japanese Journal of Cancer Research : Gann·Y KobayashiS Watanabe
Jan 1, 1991·Annals of Medicine·H T Lynch

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