Age-patterns of malaria vary with severity, transmission intensity and seasonality in sub-Saharan Africa: a systematic review and pooled analysis.

PloS One
Ilona CarneiroDavid Schellenberg

Abstract

There is evidence that the age-pattern of Plasmodium falciparum malaria varies with transmission intensity. A better understanding of how this varies with the severity of outcome and across a range of transmission settings could enable locally appropriate targeting of interventions to those most at risk. We have, therefore, undertaken a pooled analysis of existing data from multiple sites to enable a comprehensive overview of the age-patterns of malaria outcomes under different epidemiological conditions in sub-Saharan Africa. A systematic review using PubMed and CAB Abstracts (1980-2005), contacts with experts and searching bibliographies identified epidemiological studies with data on the age distribution of children with P. falciparum clinical malaria, hospital admissions with malaria and malaria-diagnosed mortality. Studies were allocated to a 3x2 matrix of intensity and seasonality of malaria transmission. Maximum likelihood methods were used to fit five continuous probability distributions to the percentage of each outcome by age for each of the six transmission scenarios. The best-fitting distributions are presented graphically, together with the estimated median age for each outcome. Clinical malaria incidence was relat...Continue Reading

References

Jul 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·J P VelemaR Adegbini
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·R W SnowB M Greenwood
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·B M GreenwoodR Hayes
Feb 1, 1995·International Journal of Epidemiology·B Kuate Defo
Sep 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·L SlutskerR W Steketee
May 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·C Rogier, J F Trape
May 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·A SchapiraB Betschart
Jul 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·R W SnowC Newbold
Nov 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·B M GreenwoodR W Snow
Aug 1, 1996·Tropical Medicine & International Health : TM & IH·A Y KituaM Tanner
Oct 1, 1996·QJM : Monthly Journal of the Association of Physicians·S J AllenJ B Clegg
Jan 1, 1997·Tropical Medicine & International Health : TM & IH·S JaffarB M Greenwood
Jan 1, 1997·Transactions of the Royal Society of Tropical Medicine and Hygiene·P ImbertD Candito
Nov 14, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K Marsh, R W Snow
Oct 14, 1998·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·J F TrapeF Simondon
Dec 23, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·D McGuinnessE Riley
Jul 8, 2000·Tropical Medicine & International Health : TM & IH·R W SnowK Marsh
Jul 18, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·S I HayR W Snow
Apr 5, 2001·Trends in Parasitology·T A SmithC Lengeler
May 18, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·D ModianoA Sawadogo
Mar 21, 2002·Tropical Medicine & International Health : TM & IH·S BonnetC Boudin
May 11, 2002·East African Medical Journal·W I Olanrewaju, A W Johnson
Dec 4, 2002·Tropical Medicine & International Health : TM & IH·Brian Greenwood
May 20, 2003·Tropical Medicine & International Health : TM & IH·M-C HenryP Carnevale
Jun 6, 2003·QJM : Monthly Journal of the Association of Physicians·K MaitlandC R J C Newton
Sep 3, 2003·Tropical Medicine & International Health : TM & IH·Kwadwo A KoramFrancis K Nkrumah
Jan 20, 2004·Tropical Medicine & International Health : TM & IH·David SchellenbergPedro Alonso
Jun 1, 1996·Parasitology Today·J F Trape, C Rogier
Oct 16, 2004·Tropical Medicine & International Health : TM & IH·Jakob P CramerUlrich Bienzle
Oct 16, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·L HenningI Felger
Dec 1, 2004·International Journal of Epidemiology·Jean-François EtardValérie Delaunay
Feb 15, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·H A GihaM I Elbashir

❮ Previous
Next ❯

Citations

Mar 19, 2014·Transactions of the Royal Society of Tropical Medicine and Hygiene·Simon KotlyarKathryn Maitland
Nov 8, 2014·Bulletin of the World Health Organization·Veronica EscamillaIrving Hoffman
Oct 4, 2014·Malaria Journal·Dalitso SegulaRobert S Heyderman
Nov 16, 2010·Bulletin of the World Health Organization·Ilona CarneiroDavid Schellenberg
Apr 22, 2011·Malaria Journal·Peter WinskillMatthew J Kirby
May 5, 2011·The American Journal of Tropical Medicine and Hygiene·Jennifer R VeraniW Evan Secor
Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ivo MuellerIngrid Felger
Dec 7, 2013·PLoS Medicine·UNKNOWN WorldWide Antimalarial Resistance Network (WWARN) DP Study Group
Mar 8, 2012·Malaria Journal·Erica M W BilligF Ellis McKenzie
Nov 30, 2012·Malaria Journal·Erica M W BilligF Ellis McKenzie
Dec 4, 2012·Malaria Journal·Umberto D'AlessandroBernard Brabin
Sep 15, 2012·BMC Infectious Diseases·Marielle Karine Bouyou-AkotetMaryvonne Kombila
Mar 22, 2012·International Journal of Health Geographics·Catherine Linard, Andrew J Tatem
Jul 4, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ilse C E HendriksenArjen M Dondorp
May 12, 2010·Expert Review of Anti-infective Therapy·Roly D GoslingDaniel Chandramohan
May 15, 2010·Science·M J Mackinnon, K Marsh
Jul 14, 2012·Médecine et maladies infectieuses·J Losimba LikwelaM Wilmet Dramaix
Mar 8, 2012·Tropical Medicine & International Health : TM & IH·S DuparcL Kellam
Sep 13, 2014·Tropical Medicine & International Health : TM & IH

❮ Previous
Next ❯

Software Mentioned

Access
MARA

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.