Age-related accumulation of toxic metals in the human locus ceruleus

PloS One
R PamphlettPhilip Doble

Abstract

Damage to the locus ceruleus has been implicated in the pathogenesis of a number of neurological conditions. Locus ceruleus neurons accumulate toxic metals such as mercury selectively, however, the presence of toxic metals in locus ceruleus neurons of people of different ages, and with a variety of disorders, is not known. To demonstrate at what age toxic metals are first detectable in the locus ceruleus, and to evaluate whether their presence is more common in certain clinicopathological conditions, we looked for these metals in 228 locus ceruleus samples. Samples were taken at coronial autopsies from individuals with a wide range of ages, pre-existing conditions and causes of death. Paraffin sections of pons containing the locus ceruleus were stained with silver nitrate autometallography, which indicates inorganic mercury, silver and bismuth within cells (termed autometallography-detected toxic metals, or AMG™). No locus ceruleus AMG neurons were seen in 38 individuals aged under 20 years. 47% of the 190 adults (ie, aged 20 years and over) had AMG locus ceruleus neurons. The proportion of adults with locus ceruleus AMG neurons increased during aging, except for a decreased proportion in the 90-plus years age group. No differe...Continue Reading

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Citations

Aug 8, 2019·PloS One·Roger PamphlettSvetlana Cherepanoff
Jul 13, 2019·Frontiers in Endocrinology·Roger PamphlettDavid P Bishop
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Dec 6, 2020·International Journal of Environmental Research and Public Health·Roger PamphlettDavid P Bishop
Oct 31, 2020·Frontiers in Neuroscience·Michael KelbermanDavid Weinshenker
Jun 12, 2021·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Onyinyechi Bede-OjimaduOrish E Orisakwe

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