Age-related alterations in axonal microstructure in the corpus callosum measured by high-gradient diffusion MRI

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Qiuyun FanSusie Y Huang

Abstract

Cerebral white matter exhibits age-related degenerative changes during the course of normal aging, including decreases in axon density and alterations in axonal structure. Noninvasive approaches to measure these microstructural alterations throughout the lifespan would be invaluable for understanding the substrate and regional variability of age-related white matter degeneration. Recent advances in diffusion magnetic resonance imaging (MRI) have leveraged high gradient strengths to increase sensitivity toward axonal size and density in the living human brain. Here, we examined the relationship between age and indices of axon diameter and packing density using high-gradient strength diffusion MRI in 36 healthy adults (aged 22-72) in well-defined central white matter tracts in the brain. A recently validated method for inferring the effective axonal compartment size and packing density from diffusion MRI measurements acquired with 300 mT/m maximum gradient strength was applied to the in vivo human brain to obtain indices of axon diameter and density in the corpus callosum, its sub-regions, and adjacent anterior and posterior fibers in the forceps minor and forceps major. The relationships between the axonal metrics, corpus callos...Continue Reading

Citations

Jul 15, 2020·Experimental Brain Research·Hidetaka Hibino, Stacey L Gorniak
May 30, 2019·Annals of Clinical and Translational Neurology·Susie Y HuangEric C Klawiter
Sep 27, 2020·The Journal of Comparative Neurology·René WesterhausenWilliam D Hopkins
Jul 1, 2020·Physics in Medicine and Biology·Daniel J SullivanAssimina A Pelegri
Jul 22, 2020·Journal of Neuroscience Methods·Ileana O JelescuKurt G Schilling
May 8, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chu-Chung HuangDerek K Jones

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