Age-Related Alterations in Retinal Tissue Perfusion and Volumetric Vessel Density

Investigative Ophthalmology & Visual Science
Ying LinJianhua Wang

Abstract

To determine age-related alterations in the retinal tissue perfusion (RTP) and volumetric vessel density (VVD) in healthy subjects. Total 148 healthy subjects (age 18 to 83 years) were enrolled and divided into four groups (G1, <35 years; G2, 35 ∼ 49 years; G3, 50 ∼ 64 years; and G4, ≥65 years). The RTP and VVD were measured at the macula. The RTP was calculated as the blood flow supplying the macular area (ϕ 2.5 mm) divided by the perfused tissue volume of the inner retina from the inner limiting membrane to the outer plexiform layer. The VVD of the macula (ϕ 2.5 mm) was calculated as the vessel density divided by the corresponding tissue volume. The RTP and VVD of the retinal vascular network and deep vascular plexus (DVP) reached a peak in G2. Compared to G2, G4 had significantly lower RTP and VVD of DVP (P < 0.05). After 35 years old, age was negatively related to the RTP (r = -0.26, P = 0.02) and VVD of the DVP (r = -0.47, P < 0.001). However, age was positively related to VVD of the superficial vascular plexus (SVP; r = 0.24, P = 0.04) in subjects aged more than 35 years. The RTP was correlated to VVD measurements (r = 0.23-0.37, P < 0.01). This is the first study to reveal the age-related alterations in the RTP and VVD d...Continue Reading

References

Feb 1, 1990·Brain : a Journal of Neurology·K L LeendersS Herold
Aug 25, 2000·Physics in Medicine and Biology·D L ThomasR J Ordidge
Jun 2, 2005·Annals of Neurology·Annemieke RuitenbergMonique M B Breteler
Oct 6, 2011·Journal of Alzheimer's Disease : JAD·Benjamin P AustinVivek Prabhakaran
Dec 24, 2011·International Journal of Biomedical Imaging·Didier AurouxMohamed Masmoudi
Jan 1, 2010·Eye and Brain·Margaret T T Wong-Riley
Feb 20, 2013·Ophthalmic Surgery, Lasers & Imaging Retina·Zvia Burgansky-EliashAdiel Barak
Jul 24, 2014·Investigative Ophthalmology & Visual Science·Nimesh B PatelRonald S Harwerth
May 30, 2015·Investigative Ophthalmology & Visual Science·Jian YuXinghuai Sun
Feb 24, 2016·Cellular and Molecular Neurobiology·Chelsea C HaysChristina E Wierenga
Feb 24, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Hong JiangJianhua Wang
Nov 8, 2016·American Journal of Ophthalmology·Min LiJianhua Wang
Jul 27, 2017·Investigative Ophthalmology & Visual Science·Yantao WeiJianhua Wang
Aug 2, 2017·Brain Research·Michael W Country
Jan 9, 2018·Current Eye Research·Liang WangJianhua Wang
Feb 28, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jennings Luu, Krzysztof Palczewski
Aug 25, 2018·Eye and Vision·Giovana Rosa GameiroJianhua Wang

❮ Previous
Next ❯

Citations

May 3, 2019·Current Eye Research·Yi LiuJianhua Wang
Dec 14, 2019·Neurology and Therapy·Jennifer NgolabRobert A Rissman
Mar 6, 2021·Investigative Ophthalmology & Visual Science·Lisette M SmidMirjam E J van Velthoven
Nov 3, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Hong JiangTania Rundek
Jun 7, 2021·Experimental Gerontology·Min FangHong Jiang
Jun 9, 2021·Investigative Ophthalmology & Visual Science·Salma FerdousJohn M Nickerson
Jun 18, 2021·European Journal of Ophthalmology·Gustavo Rosa GameiroPaulo Schor
Aug 3, 2021·Eye and Brain·Steven M SilversteinRajeev S Ramchandran
Aug 4, 2021·Scientific Reports·Edmund ArthurPeter J Snyder
Aug 31, 2021·Biomedical Optics Express·Bingyao TanLeopold Schmetterer
Oct 7, 2021·Seminars in Ophthalmology·Evita Evangelia ChristouSpiridon Konitsiotis
Nov 20, 2021·Investigative Ophthalmology & Visual Science·Kristine A TsantilasJames B Hurley
Dec 8, 2021·BMC Ophthalmology·Victor BrantlSiegfried G Priglinger

❮ Previous
Next ❯

Software Mentioned

Orion
STATISTICA
TruSoft Benoit Pro
OCTA
Matlab

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.