Abstract
Five hundred and ninety-nine patients with insulin-dependent (Type 1) diabetes mellitus were typed for Bf (factor B) polymorphism, and 318 of them for HLA-A, B and C antigens. Bf and HLA antigen frequencies were compared with those in 536 normal controls. A significant positive association between Type 1 diabetes and the rare factor B variant BfF1 was found (p less than 10(-3)), but this was present only in patients aged under 16 years at onset of the disease (p less than 0.005). There was a strongly positive linkage disequilibrium between BfF1 and HLA-B18 in the diabetic patients. This, too was especially pronounced in the juvenile onset cases, in whom it was significantly stronger than in controls (p less than 10(-3)). The known positive associations between Type 1 diabetes and HLA-B8, -B15 and -Cw3 were confirmed.
References
May 1, 1978·Diabetologia·A G Cudworth
Sep 1, 1978·British Medical Bulletin·A G Cudworth, H Festenstein
Oct 1, 1978·Tissue Antigens·J DaussetL Degos
Jun 9, 1979·Lancet·D RaumK H Gabbay
Jul 14, 1979·Lancet·J BertramsF A Gries
Sep 8, 1979·Lancet·R L KirkJ M Court
Nov 3, 1979·Lancet·J E BernalJ Haigh
Dec 8, 1979·Lancet·J BarbosaE Szalapski
Oct 1, 1979·Diabetes·R L KirkP Zimmet
Mar 1, 1979·Diabetes Care·M ChristyA Svejgaard
Oct 1, 1979·Tissue Antigens·J Bertrams, M P Baur
Jan 30, 1978·Ugeskrift for laeger·K Lundbaek
Jan 1, 1972·The Journal of Experimental Medicine·C A AlperL Watson
Jan 1, 1974·Vox Sanguinis·F H Allen
Jan 1, 1980·Immunobiology·J BertramsU Hintzen
Citations
Jul 1, 1993·Diabetes/metabolism Reviews·I Deschamps, I Khalil
Jan 1, 1981·Human Genetics·C Rittner, J Bertrams
Jan 1, 1983·Immunogenetics·B BudowleR T Acton
Dec 1, 1995·Diabetologia·T FujisawaT Ogihara
May 29, 2000·Human Immunology·Y KawabataT Ogihara
Jan 1, 1995·Baillière's Clinical Endocrinology and Metabolism·A FalorniA Lernmark
Mar 1, 1981·Journal of Neuroimmunology·J BertramsE K Kuwert
Oct 1, 1991·Annals of Medicine·I DeschampsJ Hors
Nov 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·A N Gorsuch
May 1, 1983·The Journal of Pediatrics·F KurtzG R Hauptmann
Dec 1, 1989·Clinical Immunology and Immunopathology·R Wassmuth, A Lernmark
Oct 1, 1982·Tissue Antigens·R L KirkM C Vaidya
Mar 15, 1983·Klinische Wochenschrift·J Bertrams