PMID: 7024028Jul 1, 1981Paper

Age-related association of insulin-dependent diabetes mellitus with BfF1 and the HLA-B18, BfF1 haplotype

Diabetologia
J BertramsF A Gries

Abstract

Five hundred and ninety-nine patients with insulin-dependent (Type 1) diabetes mellitus were typed for Bf (factor B) polymorphism, and 318 of them for HLA-A, B and C antigens. Bf and HLA antigen frequencies were compared with those in 536 normal controls. A significant positive association between Type 1 diabetes and the rare factor B variant BfF1 was found (p less than 10(-3)), but this was present only in patients aged under 16 years at onset of the disease (p less than 0.005). There was a strongly positive linkage disequilibrium between BfF1 and HLA-B18 in the diabetic patients. This, too was especially pronounced in the juvenile onset cases, in whom it was significantly stronger than in controls (p less than 10(-3)). The known positive associations between Type 1 diabetes and HLA-B8, -B15 and -Cw3 were confirmed.

References

May 1, 1978·Diabetologia·A G Cudworth
Sep 1, 1978·British Medical Bulletin·A G Cudworth, H Festenstein
Jun 9, 1979·Lancet·D RaumK H Gabbay
Nov 3, 1979·Lancet·J E BernalJ Haigh
Dec 8, 1979·Lancet·J BarbosaE Szalapski
Mar 1, 1979·Diabetes Care·M ChristyA Svejgaard
Jan 30, 1978·Ugeskrift for laeger·K Lundbaek
Jan 1, 1972·The Journal of Experimental Medicine·C A AlperL Watson
Jan 1, 1974·Vox Sanguinis·F H Allen

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Citations

Jul 1, 1993·Diabetes/metabolism Reviews·I Deschamps, I Khalil
Jan 1, 1981·Human Genetics·C Rittner, J Bertrams
Jan 1, 1995·Baillière's Clinical Endocrinology and Metabolism·A FalorniA Lernmark
Mar 1, 1981·Journal of Neuroimmunology·J BertramsE K Kuwert
Nov 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·A N Gorsuch
May 1, 1983·The Journal of Pediatrics·F KurtzG R Hauptmann
Dec 1, 1989·Clinical Immunology and Immunopathology·R Wassmuth, A Lernmark

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