PMID: 15374137Jan 1, 1997Paper

Age-related augmentation of stroke tendency evaluated using plasma P-selectin levels

Archives of Gerontology and Geriatrics
A SuehiroE Kakishita

Abstract

Plasma soluble P-selectin is thought to be a useful marker for thrombotic diseases. To evaluate the thrombotic state and risk of stroke in aged healthy subjects, we investigated plasma P-selectin levels in healthy subjects and ischemic stroke patients. Plasma P-selectin was measured in 67 healthy subjects and 35 aged (>or= 65 years of age) patients with chronic ischemic stroke using a sandwich enzyme-linked immunosorbent assay (ELISA). Plasma P-selectin was significantly higher in aged (>or= 65 years of age) healthy subjects than in young (< 65 years of age) healthy subjects. Significant difference did not exist between aged healthy subjects and aged stroke patients who were not receiving anti-platelet agents. Anti-platelet agent had no significant effect on plasma P-selectin levels in aged stroke patients. The amounts of P-selectin released from platelets into the plasma after stimulation with adenosin diphosphate in young and aged healthy subjects were not significantly different. Elevated levels of P-selectin in aged healthy subjects suggests the existence of a subclinical thrombotic state which can result in a stroke. Elevated P-selectin levels are not thought to be due to platelet hyperfunction.

References

Aug 30, 1992·Journal of Immunological Methods·M KatayamaY Ikeda
Nov 1, 1991·Stroke; a Journal of Cerebral Circulation·N OnoE Kakishita
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T M PalabricaB Furie
Dec 1, 1985·The Journal of Clinical Investigation·H Ishii, P W Majerus
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Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·F SakamakiM Katayama
Nov 1, 1995·Archives of Gerontology and Geriatrics·A SuehiroE Kakishitaa

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Citations

Sep 18, 2004·Archives of Gerontology and Geriatrics·A SuehiroE Kakishita
Dec 10, 2009·Journal of Thrombosis and Haemostasis : JTH·G J PenningsL Kritharides

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