Age-related behavioral changes from young to old age in male mice of a C57BL/6J strain maintained under a genetic stability program

Neuropsychopharmacology Reports
Hirotaka Shoji, Tsuyoshi Miyakawa

Abstract

Aging is thought to coincide with gradual and progressive changes in brain function and behavior over the lifetime. Our previous meta-analytic study reported age-related behavioral changes from young to middle age in male C57BL/6J mice. However, the previous study had some limitations that could affect the generalizability of the findings because of the potential influence of genetic and environmental factors on behavior, in addition to a lack of information regarding the behaviors of old-aged mice. Here, to investigate age-related behavioral changes from young to old age in mice, we analyzed the behaviors of male C57BL/6J mice from four different age groups (8, 47, 73, and 99 weeks of age at the beginning of the experiment) from a colony that had been maintained in a genetically controlled condition based on The Jackson Laboratory's Genetic Stability Program in an environmentally controlled animal facility. We used a battery of behavioral tests, including the light/dark transition, open field, elevated plus maze, hot plate, social interaction, rotarod, three-chamber social approach, prepulse inhibition, Porsolt forced swim, T-maze, Barnes maze, tail suspension, and fear-conditioning tests. Some behavioral changes occurred betw...Continue Reading

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Citations

Mar 4, 2020·International Journal of Environmental Research and Public Health·Svenja KoslowskiLaurent Meijer
Jul 28, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wing Yip Tam, Kwok-Kuen Cheung
Feb 24, 2020·GeroScience·Yin ZhaoXin A Zhang
Mar 11, 2020·Frontiers in Aging Neuroscience·Marcelo FeboThomas C Foster
Oct 8, 2020·International Journal of Molecular Sciences·Alejandro Sánchez-MelgarMairena Martín
Oct 21, 2020·Journal of Anatomy·Chayanit ChaweewannakornMasahiro Tsuchiya
Oct 25, 2020·Developmental Neurobiology·Nino LomidzeEldar Gasimov
Feb 1, 2021·Cell Calcium·Carola I RadulescuSamuel J Barnes
Feb 9, 2021·Frontiers in Aging Neuroscience·Joseph A McQuailThomas C Foster
Jun 21, 2021·Experimental Gerontology·Alyssa N CavalierThomas J LaRocca
Oct 14, 2021·Cell Reports·Hideo HagiharaTsuyoshi Miyakawa
Dec 18, 2021·Genes & Development·Takashi KaiseRyoichiro Kageyama

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Methods Mentioned

BETA
transgenic

Software Mentioned

ImagePS
SAS
ImageBM
ImageLD
ImageCSI
ImageSI
ImageTM
ImageFZ
ImageEP
ImageJ

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