Age-related bone loss and sarcopenia in men.

Maturitas
Michaël LaurentEvelien Gielen

Abstract

Bone and muscle are required for mobility but they also have endocrine and metabolic functions. In ageing as well as in many chronic diseases, bone loss and muscle atrophy occur simultaneously, leading to concomitant osteoporosis and sarcopenia. This occurs in both genders but compared with postmenopausal women, men appear to be better protected against age-related bone and muscle decay. Sex steroids (both androgens like testosterone and oestrogens like estradiol) are mainly responsible for musculoskeletal sexual dimorphism. They stimulate peak bone and muscle mass accretion during puberty and midlife, and prevent subsequent loss in ageing men but not post-menopausal women. Still, recent studies have highlighted the importance of intrinsic ageing mechanisms such as cellular senescence and oxidative stress in both genders. Sarcopenia may predispose to dysmobility, frailty, falls and fractures, but whether so-called osteosarcopenia qualifies as a distinct entity remains debated. Although randomized clinical trials in male osteoporosis are smaller and therefore underpowered for some outcomes like hip fractures, the available evidence suggests that the clinical diagnostic and therapeutic approach to male osteoporosis is largely sim...Continue Reading

Citations

Dec 5, 2019·Journal of Bone and Mineral Metabolism·Emneh HammoudRawad El Hage
May 30, 2020·Andrology·Vincenzo Rochira
Aug 3, 2019·Rheumatology International·Claudio CoralloNicola Giordano
Feb 15, 2020·International Journal of Molecular Sciences·Giulia BattafaranoAndrea Del Fattore
Jun 13, 2020·Current Osteoporosis Reports·Ben KirkGustavo Duque
Jul 18, 2020·European Geriatric Medicine·Gabriela Fagundes BelchiorGustavo Duque
Mar 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sunmin ParkSong Mee Cho
Jun 29, 2021·The Journal of Nutrition, Health & Aging·G Duque

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