Age-related bone loss in lumbar vertebrae of CW-1 female mice: a histomorphometric study

Calcified Tissue International
B Bar-Shira-MaymonM Silbermann

Abstract

Age-related changes in vertebral cortical and trabecular bone were quantitated in female CW-1 mice. Histomorphometric measurements involved the use of two different systems of image analysis: Olympus Cue 2 and Zeiss Morphomat 10. The peak of bone mass, both cortical and trabecular, was found in mice aged 13.5 months. Thereafter, there was a progressive decline in the area occupied by bone tissue and this became highly significant in elderly female and male mice. A loss of about 60% of bone tissue was encountered in both the trabecular and cortical bone, as determined by automated image analysis system. Hence, aging CW-1 mice reveal structural features consistent with vertebral osteopenia. Despite the fact that to date we lack the precise etiology for the above-mentioned phenomenon, it is suggested that the laboratory mouse might serve as an appropriate experimental model for investigations related to age-related bone loss.

References

May 1, 1987·Mechanisms of Ageing and Development·M L Tyan, W H Blahd
Feb 1, 1987·Calcified Tissue International·B E Nordin
Mar 31, 1988·The New England Journal of Medicine·L G Raisz
Jun 26, 1986·The New England Journal of Medicine·B L Riggs, L J Melton
Jan 26, 1987·The American Journal of Medicine·M J McKenna, B Frame
Jul 1, 1986·Mechanisms of Ageing and Development·A WeissM Silbermann
Jul 1, 1984·Mechanisms of Ageing and Development·D N KaluJ W Egan
Feb 1, 1983·Muscle & Nerve·M SilbermannA Reznick

❮ Previous
Next ❯

Citations

May 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R J BergmanT J Hahn
Jul 1, 1997·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·E J MurrayM R Urist
Feb 1, 1989·Calcified Tissue International·B Bar-Shira-MaymonM Silbermann
Oct 1, 1995·Bone·S C MillerW S Jee
May 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S G KaarE M Greenfield
Sep 19, 2003·Bone·Virginia L FergusonSteven J Simske
Jun 11, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bernard P HalloranSharmila Majumdar
Jul 5, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maria Almeida, Charles A O'Brien
Jan 12, 2012·Age·Sergio Portal-NúñezPedro Esbrit
Feb 1, 1990·Calcified Tissue International·M SilbermannK von der Mark
Dec 17, 2011·Revista española de geriatría y gerontología·Sergio Portal-NúñezPedro Esbrit
Feb 19, 2008·Bone·Sandra L PoliachikTed S Gross
Aug 2, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jay J CaoBernard P Halloran
Sep 14, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Emmanuel GibonStuart B Goodman
Feb 6, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jay CaoBernard P Halloran
Nov 5, 1998·Aging : Clinical and Experimental Research·G F MazzuoliD Pisani
Jan 29, 2008·Experimental Biology and Medicine·J MardonV Coxam
Feb 16, 2021·World Journal of Stem Cells·Yu-Hao ChengQin Bian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.