Age-related cellular changes in the long-lived bivalve A. islandica

Age
Heike GruberEva E R Philipp

Abstract

One of the biggest challenges to studying causes and effects of aging is identifying changes in cells that are related to senescence instead of simply the passing of chronological time. We investigated two populations of the longest living non-colonial metazoan, Arctica islandica, with lifespans that differed sixfolds. Of four investigated parameters (nucleic acid oxidation, protein oxidation, lipid oxidation, and protein instability), only nucleic acid oxidation increased with age and correlated with relative lifespan. Nucleic acid oxidation levels increased significantly faster and were significantly higher in the shorter-lived than the longer-lived population. In contrast, neither protein oxidation, lipid oxidation, nor protein stability changed over time. Protein resistance to unfolding stress when treated with urea was significantly lower overall in the shorter-lived population, and lipid peroxidation levels were higher in the longer-lived population. With the exception of nucleic acid oxidation, damage levels of A. islandica do not change with age, indicating excellent cellular maintenance in both populations. Since correlations between nucleic acid oxidation and age have also been shown previously in other organisms, and...Continue Reading

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Citations

Apr 23, 2016·The Science of the Total Environment·Sally Gaw, Chris N Glover
Oct 1, 2017·Environmental Science and Pollution Research International·Anthony BertucciMagalie Baudrimont
Oct 31, 2018·GeroScience·Nicholas J SchorkUNKNOWN Workshop Speakers and Participants
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Jun 4, 2021·Frontiers in Molecular Biosciences·Susanne HoltzeArne Sahm
Oct 8, 2021·Biological Reviews of the Cambridge Philosophical Society·Baruch RinkevichBert Hobmayer

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