PMID: 15374335May 1, 1993Paper

Age-related change in the amount of ubiquitinated histones in the mouse brain

Archives of Gerontology and Geriatrics
S MorimotoS Goto

Abstract

We investigated age-related changes in the ubiquitination of histones in mouse brains. By Western blot analysis using rabbit anti-ubiquitin antibodies, histone H2A and H2B were found to be the only proteins that are ubiquitinated in the acid-extractable nuclear proteins of both young (4-month-old) and senescent (29-month-old) mouse brains. The proportion of ubiquitinated histones was about 30% higher in senescent mice than in young ones. When total brain homogenates were analyzed similarly using somewhat different age groups of the animals, the proportion in the old animals was about 2-fold higher than that in the young.

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Citations

Jun 12, 2010·Annals of the New York Academy of Sciences·Akihiro NakamuraSataro Goto
Mar 21, 2006·Free Radical Biology & Medicine·Ramesh SharmaSataro Goto

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