Age-related changes and diseases of the ocular surface and cornea

Investigative Ophthalmology & Visual Science
Ilene K Gipson

Abstract

Aging of the ocular surface and corneal tissues, major components of the visual system, causes major eye disease and results in substantial cost in medical and social terms. These diseases include the highly prevalent dry eye disease that affects the ocular surface and its glands, leading to tear film alterations, discomfort, and decreased vision. Studies show that 14.4% of the population in the United States older than 50 years have dry eye disease and demonstrate that it is particularly prevalent among women. Annual medical costs per patient with dry eye in the United States are estimated at $783 per year, with an overall medical cost adjusted to prevalence of $3.84 billion per year. Societal costs, which include loss of productivity, are estimated per patient at $11,302 per year, with overall costs adjusted to prevalence of $55.4 billion per year. Because there are few effective treatments for the disease, more research on its etiology and mechanisms is warranted and needed. Increased public education about risk factors for the disease is also required. Another major age-related eye disease of the cornea that leads to vision impairment and potentially blindness if left untreated is Fuchs' endothelial corneal dystrophy. This ...Continue Reading

Associated Clinical Trials

Citations

Oct 21, 2014·Current Ophthalmology Reports·Alena BartakovaJeffrey L Goldberg
Dec 9, 2015·Current Eye Research·Maria ReichardSimone Baltrusch
Jul 15, 2015·Der Pathologe·S Koinzer, K Löffler
Jun 23, 2016·The Veterinary Clinics of North America. Equine Practice·Fernando Malalana
Nov 12, 2015·BioMed Research International·Alfredo RibellesManuel Diaz-Llopis
Apr 10, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Maximilian TrederNicole Eter
Apr 5, 2017·Cell and Tissue Banking·Nigel H Brookes
May 11, 2017·The Journal of Biological Chemistry·Takazumi TaniguchiPablo Argüeso
Oct 8, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·UNKNOWN Berufsverband der Augenärzte Deutschlands e. V., UNKNOWN Deutsche Ophthalmologische Gesellschaft
Jun 27, 2018·Journal of Biological Rhythms·Kenkichi Baba, Gianluca Tosini
Oct 5, 2018·Journal of Speech, Language, and Hearing Research : JSLHR·Nicholas S ReedJohn D Gottsch
Jun 21, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Idan HechtIgor Kaiserman
Sep 12, 2019·Current Eye Research·Shyam Sunder TummanapalliMaria Markoulli
Aug 1, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·David EvelethRalph A Bradshaw
Aug 3, 2018·Aging·Xiaobing HuHua Liu
Jul 28, 2020·Veterinary Ophthalmology·Hiroko IwashitaAkihiko Saito
Mar 10, 2017·Ophthalmic Epidemiology·Ying-Ying GongZhen-Sheng Gu
Jan 3, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Thomas A Fuchsluger
Mar 20, 2018·Japanese Journal of Ophthalmology·Ali Bulent CankayaPelin Yilmazbas
Aug 30, 2020·The British Journal of Ophthalmology·Jovany Jeomar FrancoRoberto Pineda
Mar 10, 2016·Npj Aging and Mechanisms of Disease·Jonathan B LinRajendra S Apte
May 19, 2018·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Allison M McKendrickBao N Nguyen
Jun 27, 2019·Investigative Ophthalmology & Visual Science·Manikkuwadura Eranda Harshan De SilvaHolly R Chinnery
Apr 26, 2019·Frontiers in Bioengineering and Biotechnology·Brecken J BlackburnWilliam J Dupps
Nov 12, 2016·International Ophthalmology·Nuria GarzónFrancisco Argüeso
Apr 26, 2019·Investigative Ophthalmology & Visual Science·Antonio Di ZazzoStefano Bonini
Sep 3, 2014·Journal of Ophthalmology·Laura OttobelliLuca Rossetti
Dec 3, 2020·Investigative Ophthalmology & Visual Science·Pawan Kumar SinghAshok Kumar
Mar 27, 2021·British Journal of Pharmacology·Chloe N ThomasLisa J Hill
May 23, 2021·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Marcelina SobczakBarbara Pierścionek
May 23, 2021·Acta Ophthalmologica·Lith Elizabeth Wienholtz FrifeltAmardeep Singh
Jun 8, 2021·Progress in Retinal and Eye Research·Romina Mayra Lasagni VitarGiulio Ferrari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cataract and Refractive Surgery
Y Shiuey, M Moshirfar
Cornea
S E Wilson, William M Bourne
Investigative Ophthalmology & Visual Science
Mihaela L PopescuEllen E Freeman
© 2021 Meta ULC. All rights reserved